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Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom.
Diseases
September 2024
Nottingham Breast Cancer Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Article Synopsis
- Poor survival rates in periampullary cancer indicate a need for better biomarkers and new treatments.
- A study examined the protein expressions of thioredoxin (Trx), thioredoxin-interacting protein (TxNIP), and thioredoxin reductase (TrxR) in patients with pancreatic ductal adenocarcinoma (PDAC) and other related cancers using immunohistochemistry.
- Results showed that high TrxR expression was linked to lymph node metastasis, while higher Trx expression was associated with improved overall survival, highlighting the prognostic value of these proteins in periampullary cancers.
Molecular aspects of BRAF and HER2 in prognosis of periampullary carcinoma.
Pancreatology
November 2024
Central Molecular Lab, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India; Department of GI Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India. Electronic address:
Background: Biological behaviour of Periampullary cancers (PACS) differs from pancreatic head cancer, and analysis of molecular alteration is needed. BRAF and HER2 are keys members of the RAS/RAF and EGFR pathway, playing roles in prognostic markers and therapeutic targets.
Methods: A study on 89 PACS patients, undergoing Whipple Pancreaticoduodenectomy, PCR-RFLP, and qPCR methods used for SNP and mRNA expression studies.
Preliminary response to Tislelizumab plus chemotherapy drugs in patient with periampullary carcinoma: a report of one case and a literature review.
Front Immunol
July 2024
Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Article Synopsis
- - Periampullary carcinoma is a malignant tumor found in the pancreas, bile duct, duodenum, or ampulla of Vater, and surgery is the main treatment, but high recurrence rates remain a challenge.
- - The tumor has two histological subtypes: intestinal (IN) and pancreaticobiliary (PB), each requiring different chemotherapy drugs, with gemcitabine for PB and 5-FU for IN, yet patient outcomes are often poor.
- - A case study showed promising results using a combination of immunotherapy (Tislelizumab) and chemotherapy after identifying certain high-risk features in a patient, suggesting a potential new approach for treating recurrent periampullary carcinoma.
Serum miR-215-5p, miR-192-5p and miR-378a-5p as novel diagnostic biomarkers for periampullary adenocarcinoma.
Pathol Res Pract
August 2024
Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India. Electronic address:
Objective: MicroRNAs (miRNAs) are present in human serum in a stable form. Circulating miRNAs are increasingly recognized as promising biomarkers for early cancer detection. The aim of this study was to identify serum miRNAs as biomarkers for periampullary adenocarcinoma (PAC).
View Article and Find Full Text PDFChallenges of Diagnosis: Periampullary Mass-Induced Obstructive Jaundice in a Young Woman.
Cureus
May 2024
Department of Cardiology, Max Super Speciality Hospital, Delhi, IND.
Periampullary cancers, which include pancreatic adenocarcinoma, ampullary cancer, distal cholangiocarcinoma, and duodenal cancer, present diagnostic and management challenges due to their aggressive nature and nonspecific symptoms. We describe a case of a female patient, age 20, who had obstructive jaundice brought on by a periampullary tumor. Despite difficulties in diagnosis and treatment, including failed endoscopic retrograde cholangiopancreatography (ERCP), the patient underwent a successful pancreaticoduodenectomy (Whipple's resection), and subsequent immunohistochemistry revealed adenocarcinoma with a mixed immunophenotype expressing duodenal and pancreatic markers.
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