Acetaminophen: A Liver Killer or Thriller.

Cureus

Anesthesiology and Perioperative Medicine, Al Ahalia Hospital Mussafah, Abu Dhabi, ARE.

Published: October 2023

Acetaminophen, or paracetamol, ranks among the most extensively utilized analgesic and antipyretic medications globally. The administration of acetaminophen to individuals with underlying liver disease has long sparked concerns regarding the potential risk of hepatotoxicity. However, the available literature and recommendations consider it a safe option in all forms of liver diseases and is deemed safe when used at recommended doses. This article aims to offer a concise review of the pharmacokinetics, toxicity profile, and the intricate considerations surrounding the safety of acetaminophen in patients with liver disease. By delving into the liver-acetaminophen interactions, we seek to provide a nuanced perspective on the use of acetaminophen in this critical patient population.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645398PMC
http://dx.doi.org/10.7759/cureus.47071DOI Listing

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