Antibody glycosylation correlates with disease progression in SIV- coinfected cynomolgus macaques.

Objectives: Tuberculosis (TB) remains a substantial cause of morbidity and mortality among people living with human immunodeficiency virus (HIV) worldwide. However, the immunological mechanisms associated with the enhanced susceptibility among HIV-positive individuals remain largely unknown.

Methods: Here, we used a simian immunodeficiency virus (SIV)/TB-coinfection Mauritian cynomolgus macaque (MCM) model to examine humoral responses from the plasma of SIV-negative ( = 8) and SIV-positive ( = 7) MCM 8-week postinfection with ().

Results: Antibody responses to were impaired during SIV coinfection. Elevated inflammatory bulk IgG antibody glycosylation patterns were observed in coinfected macaques early at 8-week post- infection, including increased agalactosylation (G0) and reduced di-galactosylation (G2), which correlated with endpoint bacterial burden and gross pathology scores, as well as the time-to-necropsy.

Conclusion: These studies suggest that humoral immunity may contribute to control of TB disease and support growing literature that highlights antibody Fc glycosylation as a biomarker of TB disease progression.