Electrospinning's production method has been streamlined and perfected because to advancements in technology and increased demand. While working with electrospun fibers, it is crucial to ensure that they are collected in the correct orientation. Electrospun fibers can be either aligned or random. In contrast to randomly oriented fibers, all aligned ones will point in the same direction. Our results show that a low-cost, tailored electrospinning device can achieve equivalent performance to that of a commercially available system. High voltage (up to 36 kV) and nanofiber orientation adjustments are now being made to the proposed device. A high-voltage direct-current electrical power supply that is custom-built per order and wired by hand. Two specialized collectors, one portable and manufactured from conductive material for random nanofibers, and the other an inexpensive rotational drum collector for aligned nanofibers, have been developed to allow for precise orientation control. By applying Image J software to scanning electron micrographs, we were able to determine the average diameter and orientation of the fibers produced by the electrospinning apparatus, demonstrating its potential to produce nanoscale directed fibers. Because of this research, it's possible that schools will be able to afford an electrospinning system at a price far lower than the current market price.
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http://dx.doi.org/10.1016/j.ohx.2023.e00483 | DOI Listing |
PLoS One
January 2025
College & Hospital of Stomatology, Key Laboratory of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, China.
Aligned electrospinning membranes (Align) have demonstrated the potential to enhance wound healing by establishing a regenerative microenvironment surrounding the wound; However, the precise mechanism underlying its facilitation of healing remains unclear. To elucidate aligned electrospun fiber membrane's role in accelerating wound healing and improving its quality, we conducted a comprehensive analysis. Firstly, in vivo experiments confirmed that Align promotes wound healing.
View Article and Find Full Text PDFDiscov Nano
January 2025
National Nanotechnology Laboratory for Agriculture (LNNA), Embrapa Instrumentação, 1452 XV de Novembro St., São Carlos, SP, 13560-970, Brazil.
Multifunctional membranes applied to biomedical materials become attractive to support the biological agents and increase their properties. In this study, biopolymeric fibers based on polycaprolactone (PCL) and pectin (PEC) were reinforced with faujasite zeolite (FAU) for cloxacillin antibiotic (CLX) loading. FAU with a high specific surface area (347 ± 8 m g), high crystallinity and particles with a diameter of up to 100 nm were produced under optimized synthesis conditions (100 °C/4 h).
View Article and Find Full Text PDFMacromol Rapid Commun
January 2025
UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Antimicrobial resistance poses a growing threat to public health globally. Multidrug resistant Pseudomonas (P.) aeruginosa is detected in many infected wounds and is very challenging to treat with antibiotics.
View Article and Find Full Text PDFMacromol Biosci
January 2025
Institute for Technical Chemistry, Macromolecular Chemistry, TU Braunschweig, Hagenring 30, 38106, Braunschweig, Germany.
Implant-integrated drug delivery systems that enable the release of biologically active factors can be part of an in situ tissue engineering approach to restore biological function. Implants can be functionalized with drug-loaded nanoparticles through a layer-by-layer assembly. Such coatings can release biologically active levels of growth factors.
View Article and Find Full Text PDFRegen Biomater
December 2024
Department of Trauma Surgery, Orthopaedic Surgery and Plastic Surgery, University Medical Center Göttingen, University of Göttingen, Göttingen 37075, Germany.
Electrospinning is a remarkably straightforward and adaptable technique that can be employed to process an array of synthetic and natural materials, resulting in the production of nanoscale fibers. It has emerged as a novel technique for biomedical applications and has gained increasing popularity in the research community in recent times. In the context of tissue repair and tissue engineering, there is a growing tendency toward the integration of biomimetic scaffolds and bioactive macromolecules, particularly proteins and growth factors.
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