AI Article Synopsis
- * Treatments included extended use of tecovirimat and starting ART to boost the immune response.
- * Findings showed significant monkeypox virus replication in skin cells, indicating that continuous viral activity could be the reason for prolonged illness in these patients.
Article Abstract
We report 3 complicated and prolonged cases of mpox in people with advanced human immunodeficiency virus (HIV) not on antiretroviral therapy (ART) at mpox diagnosis. Multiple medical countermeasures were used, including prolonged tecovirimat treatment and immune optimization with ART initiation. Immunofluorescence of skin biopsies demonstrated a dense immune infiltrate of predominantly myeloid and CD8+ T cells, with a strong type I interferon local response. RNAscope detected abundant replication of monkeypox virus (MPXV) in epithelial cells and dendritic cells. These data suggest that prolonged mpox in people with advanced HIV may be due to ongoing MPXV replication, warranting aggressive medical countermeasures and immune optimization.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10965209 | PMC |
| http://dx.doi.org/10.1093/infdis/jiad532 | DOI Listing |
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