AI Article Synopsis
- Kidney transplant recipients (KTRs) show lower antibody levels in response to SARS-CoV-2 vaccination compared to healthy controls (HCs).
- A study analyzed plasma from 78 KTRs and 12 HCs using phage display to map their antibody responses to the virus.
- Both KTRs and HCs recognized similar neutralizing epitopes, suggesting that the reduced vaccine efficacy in KTRs isn't due to a lack of epitope recognition.
Article Abstract
Kidney transplant recipients (KTRs) develop decreased antibody titers to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination compared to healthy controls (HCs), but whether KTRs generate antibodies against key epitopes associated with neutralization is unknown. Plasma from 78 KTRs from a clinical trial of third doses of SARS-CoV-2 vaccines and 12 HCs underwent phage display immunoprecipitation and sequencing (PhIP-Seq) to map antibody responses against SARS-CoV-2. KTRs had lower antibody reactivity to SARS-CoV-2 than HCs, but KTRs and HCs recognized similar epitopes associated with neutralization. Thus, epitope gaps in antibody breadth of KTRs are unlikely responsible for decreased efficacy of SARS-CoV-2 vaccines in this immunosuppressed population. Clinical Trials Registration. NCT04969263.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095532 | PMC |
| http://dx.doi.org/10.1093/infdis/jiad534 | DOI Listing |
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