Background: This study evaluated the effect of sertraline with desvenlafaxine and sertraline with mirtazapine on HAM-D score and inflammatory markers (IL-6 and TNF-α levels) in major depressive disorder.
Methods: Patients (18-60 years) with MDD diagnosed by DSM-V criteria and HAM-D score 18 or more were included ( = 60). Group A patients ( = 30) received sertraline 50 mg/day and desvenlafaxine 50 mg/day. Group B patients ( = 30) received sertraline 50 mg/day and mirtazapine 30 mg/day. All patients were followed up for 8 weeks for the evaluation of clinical efficacy, safety, serum IL-6, and TNF-α levels.
Results: Our study showed a comparatively similar and statistically significant ( < 0.05) reduction in HAM-D score in both groups in the 4th and 8th week of the treatment. Both drug combinations significantly ( < 0.05) decreased serum IL-6 and TNF-α after 8 weeks of treatment.
Conclusion: The present study suggests that the combination therapy (as treatment initiation) with sertraline and desvenlafaxine, and sertraline with mirtazapine is effective and well tolerated in MDD patients with moderate to severe depression, and their therapeutic efficacy is accompanied by decreased inflammatory markers (serum IL-6 and TNF-α).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/13651501.2023.2287754 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effectiveness of Antidepressants in Combination with Psychotherapy.
J Ment Health Policy Econ
March 2024
Department of Health Administration and Policy, George Mason University, Fairfax, VA 19122, USA,
Background: Consensus-guidelines for prescribing antidepressants recommend that clinicians should be vigilant to match antidepressants to patient's medical history but provide no specific advice on which antidepressant is best for a given medical history.
Aims Of The Study: For patients with major depression who are in psychotherapy, this study provides an empirically derived guideline for prescribing antidepressant medications that fit patients' medical history.
Methods: This retrospective, observational, cohort study analyzed a large insurance database of 3,678,082 patients.
Evening Chronotypes With Depression Report Poorer Outcomes of Selective Serotonin Reuptake Inhibitors: A Survey-Based Study of Self-Ratings.
Biol Psychiatry
July 2024
Brain and Mind Centre, the University of Sydney, Sydney, New South Wales, Australia.
Background: Preliminary evidence suggests that evening chronotype is related to poorer efficacy of selective serotonin reuptake inhibitors. It is unknown whether this is specific to particular medications, self-rated chronotype, or efficacy.
Methods: In the Australian Genetics of Depression Study (n = 15,108; 75% women; 18-90 years; 68% with ≥1 other lifetime diagnosis), a survey recorded experiences with 10 antidepressants, and the reduced Morningness-Eveningness Questionnaire was used to estimate chronotype.
Trace analysis of 47 psychotropic medications in environmental samples by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).
J Chromatogr A
January 2024
Guangdong Environmental Protection Key Laboratory of Microbiology and Ecological Safety, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, PR China. Electronic address:
Article Synopsis
- Psychotropic medications are widely prescribed but can harm the environment, leading to a need for effective detection methods.
- The study created a reliable method using ultra-performance liquid chromatography to analyze 47 psychotropic drugs across various water and sludge samples.
- The findings showed that many of these medications persist in wastewater treatment plants, highlighting issues with their removal and potential environmental impact.
Sertraline with desvenlafaxine and sertraline with mirtazapine as treatment initiation in MDD patients with moderate to severe depression and effect on inflammatory markers.
Int J Psychiatry Clin Pract
March 2024
Department of Psychiatry, University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital, New Delhi, India.
Background: This study evaluated the effect of sertraline with desvenlafaxine and sertraline with mirtazapine on HAM-D score and inflammatory markers (IL-6 and TNF-α levels) in major depressive disorder.
Methods: Patients (18-60 years) with MDD diagnosed by DSM-V criteria and HAM-D score 18 or more were included ( = 60). Group A patients ( = 30) received sertraline 50 mg/day and desvenlafaxine 50 mg/day.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!