AI Article Synopsis
- Unveiling gene co-expression networks can provide insights into how bacterial pathogens adapt to host environments.
- Co-PATHOgenex is an interactive web app that allows users to build networks from gene co-expressions by defining their own parameters, making analysis easier to interpret.
- The app features stress stimulons for different bacterial species, aiding in discovering gene products linked to specific stress conditions that were not previously recognized.
Article Abstract
Unveiling gene co-expression networks in bacterial pathogens has the potential for gaining insights into their adaptive strategies within the host environment. Here, we developed Co-PATHOgenex, an interactive and user-friendly web application that enables users to construct networks from gene co-expressions using custom-defined thresholds (https://avicanlab.shinyapps.io/copathogenex/). The incorporated search functions and visualizations within the tool simplify the usage and facilitate the interpretation of the analysis output. Co-PATHOgenex also includes stress stimulons for various bacterial species, which can help identify gene products not previously associated with a particular stress condition.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783046 | PMC |
| http://dx.doi.org/10.1128/spectrum.02781-23 | DOI Listing |
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