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Harnessing Spatiotemporal-Specific Tumorous Exosome Dynamics: Ultra-Sensitive Lanthanide Luminescence Detection Strategy Enabled by Exosomal Membrane Engineering for Melanoma Immunotherapy Monitoring.
ACS Appl Mater Interfaces
September 2024
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P. R. China.
Focused on the newly secreted tumorous exosomes during melanoma immunotherapy, this work has pioneered an ultra-sensitive spatiotemporal-specific exosome detection strategy, leveraging advanced exosomal membrane engineering techniques. The proposed strategy harnesses the power of amplified lanthanide luminescence signals on these exosomes, enabling precise and real-time monitoring of the efficacy of melanoma immunotherapy. The methodology comprises two pivotal steps.
View Article and Find Full Text PDFCancer testis antigen burden (CTAB): a novel biomarker of tumor-associated antigens in lung cancer.
J Transl Med
February 2024
OmniSeq (Labcorp Oncology), Buffalo, NY, USA.
Background: Cancer-testis antigens (CTAs) are tumor antigens that are normally expressed in the testes but are aberrantly expressed in several cancers. CTA overexpression drives the metastasis and progression of lung cancer, and is associated with poor prognosis. To improve lung cancer diagnosis, prognostic prediction, and drug discovery, robust CTA identification and quantitation is needed.
View Article and Find Full Text PDF[Identification of immunotherapy-treated responder patients in pancreatic cancer with transcriptomic tools].
Med Sci (Paris)
November 2023
Université Claude Bernard Lyon 1, 69000 Lyon, France - Cancer Research Center of Lyon, UMR Inserm 1052, CNRS 5286, Lyon, France - Centre Léon Bérard, Lyon, France.
Is there an association between lymph node size and hyperprogression in immunotherapy-treated patients?
Rom J Intern Med
March 2024
Department of Internal Medicine, Military Cancer Center, Royal Medical Services, Amman, Jordan.
Background: Hyperprogressive disease (HPD) can be described as an accelerated increase in the growth rate of tumors combined with rapid clinical deterioration observed in a subset of cancer patients undergoing immunotherapy, specifically with immune checkpoint inhibitors (ICIs). The reported incidence of HPD ranges from 5.9% to 43.
View Article and Find Full Text PDFIdentification of CD8 T Cell Related Biomarkers in Ovarian Cancer.
Front Genet
May 2022
Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation for Cancer Medicine, Guangzhou, China.
Immunotherapy is a promising strategy for ovarian cancer (OC), and this study aims to identify biomarkers related to CD8 T cell infiltration to further discover the potential therapeutic target. Three datasets with OC transcriptomic data were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Two immunotherapy treated cohorts were obtained from the Single Cell Portal and Mariathasan's study.
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