AI Article Synopsis
- Human milk oligosaccharides (HMO) are a critical component of breast milk, making up 5 to 20 g per liter and showing complex structures with over 150 types identified.
- Research indicates that HMOs play significant roles in infant development, aiding gut health, supporting immune function, and promoting neurodevelopment.
- While some infant formulas contain HMOs, their health benefits are still under investigation, and future studies may explore their use for preterm infants and in preventing chronic diseases related to the immune and nervous systems.
Article Abstract
Human milk oligosaccharides (HMO) represent the third largest component of human breast milk (BM). The BM level is comprised between 5 to 20 g per liter and they have a great structural complexity with more than 150 HMO characterized to date. In this review, we present a summary of the main experimental and clinical data that have demonstrated their multiple biological roles in infants such as for gut development, microbiota, immune protection and neurodevelopment. Some HMO-enriched infant formulas are available yet, even if their benefits on the infant health remain to be confirmed. Further researches could allow therapeutic use in preterm newborns or in infants with intestinal diseases. Experimental data suggest that they could also be used in the prevention of some chronic diseases with immunometabolic or neurodevelopmental components.
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| http://dx.doi.org/10.1051/medsci/2023164 | DOI Listing |
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