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Monitoring SARS-CoV-2 variants with complementary surveillance systems: risk evaluation of the Omicron JN.1 variant in France, August 2023 to January 2024.
Euro Surveill
January 2025
National Reference Center for Respiratory Viruses, Hospices Civils de Lyon, CIRI, INSERM U1111, University Claude Bernard Lyon 1, Lyon, France.
BackgroundEarly detection and characterisation of SARS-CoV-2 variants have been and continue to be essential for assessing their public health impact. In August 2023, Santé publique France implemented enhanced surveillance for BA.2.
View Article and Find Full Text PDFESCAPE Study: Cannabidiol Use in Patients Treated for Substance Use Disorders, Prevalence of Use, and Characteristics of Users.
Eur Addict Res
December 2024
Nantes Université, CHU Nantes, Centre d'Evaluation et d'Information sur la Pharmacodépendance-Addictovigilance (CEIP-A), Service de Pharmacologie Clinique, Nantes, France.
Article Synopsis
- Cannabidiol (CBD) is a cannabis compound with potential medical benefits, and this study aimed to assess its usage among patients in substance use disorder treatment.
- Out of 183 patients, 38.2% reported using CBD in the past year, but 63% had recently stopped, mainly due to ineffectiveness and cost concerns.
- CBD users tend to be younger with psychiatric comorbidities and prefer inhalation methods, and the study highlights the importance for clinicians to regularly ask about CBD use due to potential drug interactions.
Using cluster-based permutation tests to estimate MEG/EEG onsets: How bad is it?
Eur J Neurosci
January 2025
School of Psychology and Neuroscience, College of Medical, Veterinary and Life, Sciences, University of Glasgow, Glasgow, UK.
Localising effects in space, time and other dimensions is a fundamental goal of magneto- and electroencephalography (EEG) research. A popular exploratory approach applies mass-univariate statistics followed by cluster-sum inferences, an effective way to correct for multiple comparisons while preserving high statistical power by pooling together neighbouring effects. Yet, these cluster-based methods have an important limitation: each cluster is associated with a unique p-value, such that there is no error control at individual timepoints, and one must be cautious about interpreting when and where effects start and end.
View Article and Find Full Text PDFHyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer (CHIPOR): a randomised, open-label, phase 3 trial.
Lancet Oncol
December 2024
Centre Hospitalier Lyon Sud, Pierre-Bénite, France; CICLY, Université Lyon 1, Lyon, France.
Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) at interval cytoreductive surgery for ovarian cancer improves overall survival but its role in recurrent disease is uncertain. We aimed to compare outcomes in patients treated with or without HIPEC during surgery for recurrent ovarian cancer.
Methods: The multicentre, open-label, randomised, phase 3 CHIPOR trial was conducted at 31 sites in France, Belgium, Spain, and Canada, and enrolled patients with first relapse of epithelial ovarian cancer at least 6 months after completing platinum-based chemotherapy.
Equimolar oxygen-nitrous oxide (EMONO) in dental pediatric care: which patients achieve therapeutic effects? A French national exploratory prospective observational multicenter study.
Eur Arch Paediatr Dent
November 2024
Centre for Evaluation and Information on Pharmacodependence, Clinical Pharmacology Department, Nantes University, Nantes Hospital, F-44000, Nantes, France.
Purpose: Equimolar oxygen-nitrous oxide mixture (EMONO) is considered as a reference for dental care in children. Completion of dental treatment has usually been used as a criterion to assess EMONO treatment. However, other patient-reported outcomes are needed.
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