Background: The American Psychiatric Association guidelines for the treatment of patients with schizophrenia state that the utility of antipsychotic therapeutic drug monitoring (TDM) remains unclear, except for clozapine or assessing adherence. The aim of this study was to investigate the extent and impact of antipsychotic TDM in inpatient practice to improve its utilization.
Methods: Patients with antipsychotic blood levels drawn between May 1, 2021 and January 31, 2023 were invited to consent for retrospective chart data analysis to determine the influence of antipsychotic blood levels on their treatment. Approximately 42% of patients consented. Data collected from the patients' electronic medical records included age, ethnicity, race, sex, diagnosis, comorbidities, adverse drug reactions, medications, doses and frequency, antipsychotics and levels, laboratory values, and treatment history. Comparisons were made between antipsychotic levels that were within and outside the therapeutic range and the status of antipsychotic regimen adjustments.
Results: A total of 135 antipsychotic levels from 40 inpatients were analyzed. Approximately 48% of the levels were appropriately drawn, whereas 52% were inappropriately drawn. Clozapine had the highest TDM rate (59%) and the most common diagnoses were schizophrenia (45%) and schizoaffective disorder (32.5%). More levels were appropriately drawn for clozapine (47.3% versus 24.3%) than for risperidone (41% versus 46.2%). Appropriately drawn clozapine levels correlated with higher daily doses and levels at or above the therapeutic threshold of 350 ng/mL.
Conclusions: Most antipsychotic drug levels were inappropriately drawn, emphasizing the complexity and potential for errors in TDM. Although more patients were prescribed risperidone, clozapine had the highest TDM rate. Clinicians were more likely to keep antipsychotic regimens unchanged for appropriately drawn levels and adjust doses for inappropriately drawn levels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/FTD.0000000000001156 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Seasonal Fluctuation in the Incidence of Congenital Hypothyroidism Across Different Temperate Zones of China.
Birth Defects Res
January 2025
National Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, Chengdu, China.
Background: Seasonality in the incidence of congenital hypothyroidism (CH) has been identified in several countries and different conclusions have been drawn. The objective of this study was to examine whether this seasonality is also observable in China and how it manifests across different temperate zones.
Methods: Data on CH cases and screened neonates between January 1, 2014, and September 30, 2022, by year and season, were sourced from the Chinese Newborn Screening Information System.
Non-colorectal Cancer Screening and Vaccinations in Patients with Inflammatory Bowel Disease: Expert Review.
Clin Gastroenterol Hepatol
January 2025
Inflammatory Bowel Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville FL. Electronic address:
Description: The aim of this American Gastroenterological Association (AGA) Clinical Practice Update (CPU) is to provide best practice advice (BPA) statements for gastroenterologists and other health care providers who provide care to patients with inflammatory bowel disease (IBD). The focus is on IBD-specific screenings (excluding colorectal cancer screening, which is discussed separately) and vaccinations. We provide guidance to ensure that patients are up to date with the disease-specific cancer screenings, vaccinations, as well as advice for mental health and general wellbeing.
View Article and Find Full Text PDFThe Post-Acute COVID-19-Vaccination Syndrome in the Light of Pharmacovigilance.
Vaccines (Basel)
December 2024
Central Institute of Clinical Chemistry and Laboratory Diagnostics, Medical Faculty, Heinrich Heine University, University Hospital, 40255 Düsseldorf, Germany.
Clinical studies show that SARS-CoV-2 vaccination sometimes entails a severe and disabling chronic syndrome termed post-acute-COVID-19-vaccination syndrome (PACVS). PACVS shares similarities with long COVID. Today, PACVS is still not officially recognised as a disease.
View Article and Find Full Text PDFEvaluating the Appropriateness of Selected Foundry Sands for the Casting of Reactor Housings: A Study Based on Physicochemical Characterization Outcomes.
Materials (Basel)
December 2024
Faculty of Geology, Geophysics and Environmental Protection, AGH University of Krakow, al. A. Mickiewicza 30, 30-059 Krakow, Poland.
In the case of desulfurization and spheroization of cast iron using the in-mold method, in which the treated cast iron is poured into the reaction chamber and placed in the casting mold, the mineral raw material of the mold should support these processes. Therefore, it is important to know the physicochemical properties of the materials selected for the production of casting molds and to learn about the phenomena occurring during their pouring. The research presented in this paper was carried out on quartz, magnesite, chromite, and olivine sands.
View Article and Find Full Text PDFFactor structures of the Korean version of the Need for Cognition Scale Short Form (K-NfC-S) among Korean older adults.
Aging Ment Health
January 2025
Department of Psychology, Chung-Ang University, Seoul, South Korea.
Objectives: This study examined the factor structure of the short-form Korean version of the Need for Cognition Scale (K-NfC-S) among older adults in South Korea.
Method: Drawn from the 2020 Korean Media Panel Study, a total of 2,281 adults aged 65 years and older were analysed. We measured the need for cognition using the 15-item K-NfC-S.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!