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Ugeskr Laeger

Klinisk Farmakologisk Enhed, Sjællands Universitetshospital, Roskilde.

Published: November 2023

AI Article Synopsis

  • - This review discusses the relationship between psychotropic drugs and the risk of developing angle-closure glaucoma in certain patients.
  • - Patients predisposed to or diagnosed with glaucoma should have regular check-ups with an ophthalmologist, despite most psychotropic drugs not being outright contraindicated.
  • - The review highlights that while it's uncertain if serotonin reuptake inhibitors affect glaucoma risk, tricyclic antidepressants, benzodiazepines, and certain antipsychotics should be used cautiously in predisposed individuals.

Article Abstract

This review offers a summary of the current knowledge of pshychotropic drugs and glaucoma. If exposed to psychotropic drugs, some patients may develop angle-closure glaucoma. Although rarely contraindicated, exposed predisposed and diagnosed patients should be followed-up by an ophthalmologist. It is still unclear if serotonin reuptake inhibitors increase the risk of angle-closure glaucoma. Tricyclic antidepressants and benzodiazepines should be used with caution in predisposed patients. The same applies to antipsychotic drugs, where first-generation antipsychotic drugs might have a smaller impact on the intraocular pressure than second-generation antipsychotic drugs.

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