We report a single-frequency, linearly polarized gain-switched, distributed feedback (DFB), 2-µm thulium doped silica fiber laser (TDFL), with an effective cavity length of 2.5 mm. The cavity is based on a heavily thulium doped non-polarization-maintaining silica fiber and composed of a π-phase-shifted fiber Bragg grating (FBG) with a total FBG length of 35 mm. The DFB FBG was written by femtosecond-laser point-by-point (PbP) method. In-band pumping scheme is chosen with a 1550 nm nanosecond pulsed erbium-doped silica fiber laser pump. Single-longitudinal, linearly polarized, gain-switched TDFL at 2002 nm, with a recorded shortest pulse duration of 4.7 ns, a repetition rate of 20 kHz, a maximum peak power of 170 W, and single pulse energy of 0.8 µJ, has been obtained, benefitting from the ultrashort DFB cavity made by the femtosecond laser direct-writing method.
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http://dx.doi.org/10.1364/OE.505036 | DOI Listing |
Pigment Cell Melanoma Res
January 2025
QIMA Life Sciences, QIMA Monasterium GmbH, Münster, Germany.
Epidermal melanocytes form synaptic-like contacts with cutaneous nerve fibers, but the functional outcome of these connections remains elusive. In this pilot study we used our fully humanized re-innervated skin organ culture model to investigate melanocyte-nerve fiber interactions in UV-B-induced melanogenesis. UV-B-irradiation significantly enhanced melanin content and tyrosinase activity in re-innervated skin compared to non-innervated controls, indicating that neuronal presence is essential for exacerbating pigmentation upon UV-B irradiation in long-term culture.
View Article and Find Full Text PDFPurpose Of Review: This review focuses on recent advancements in laser technologies used in urology, particularly in enucleation, vaporization, lithotripsy, and focal laser ablation (FLA). The growing use of the thulium fiber laser (TFL) and the development of pulsed thulium lasers (p-Tm:YAG) highlight the relevance of this review, as these innovations aim to improve precision and outcomes in urological procedures.
Recent Findings: Recent studies have shown the advantages of TFL in achieving precise tissue ablation, reduced retropulsion offered by the Moses technology in holmium lasers, and the potential of pulsed thulium lasers for more precise control of the effects on tissues.
J Control Release
January 2025
State Key Laboratory of Separation Membranes and Membrane Processes & Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes (MOE) & Tianjin Key Laboratory of Hollow Fiber Membrane Materials and Processes, School of Materials Science and Engineering, Tiangong University, Tianjin 300387, China. Electronic address:
Clinical benefits of immunotherapy in colorectal cancer (CRC) are limited due to the low immunogenicity and immunosuppressive tumor microenvironment. Fusobacterium nucleatum (Fn) is discovered to colonize CRC tumors and dampen immunotherapy by fostering an immunosuppressive TME. Herein, a controllable "Shielding-deshielding" N-acetylgalactosamine (GalNAc)-derived photothermal nanotherapeutic is developed to mediate cascade targeting toward tumor and intratumoral Fn for enhanced photothermal-immunotherapy.
View Article and Find Full Text PDFBiomater Sci
January 2025
Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, 1088 Xueyuan Boulevard, Shenzhen, Guangdong 518055, China.
Photothermal treatment has attracted immense interest as a promising approach for biomedical applications such as cancer ablation, yet its effectiveness is often limited by insufficient laser penetration and challenges in achieving efficient targeting of photothermal agents. Here we developed a transvascular interventional photothermal therapy (Ti-PTT), which employed a small-sized microcatheter (outer diameter: 0.60 mm, 1.
View Article and Find Full Text PDFFish Shellfish Immunol
January 2025
Jiangxi Province Key Laboratory of Synthetic Pharmaceutical Chemistry, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, China. Electronic address:
The large-scale mining and utilization of rare earth elements have significantly increased their concentration in the environment, especially in regions surrounding mining areas. These environmentally-enriched rare earth elements accumulate in agricultural products and organisms through soil and water, potentially impacting in human health through the food chain. Erbium (Er), a rare earth element of the lanthanide series (Group IIIB), plays a crucial role in various modern technological applications.
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