Accurate estimation of the diffuse attenuation coefficient of photosynthetically active radiation, K(PAR), is critical for understanding and modeling key physical, chemical, and biological processes in waters. In this study, a deep learning model (DLKPAR) was developed for remotely estimating K(PAR). Compared to the traditional empirical algorithms and semi-analytical algorithm, DLKPAR demonstrated an improvement in the model's stability and accuracy. By using in situ NOMAD data to evaluate the model's performance, DLKPAR had lower root mean square difference (RMSD; 0.028 vs. 0.030-0.048 m) and mean absolute relative difference (MARD; 0.14 vs. 0.17-0.25) and higher R (0.94 vs. 0.82-0.94). The statistical results of the matchup NOMAD and Argo data to the MODIS also indicated DLKPAR improves the inversion accuracy of K(PAR) and could be applied to remotely estimate K(PAR) in the global oceans. Therefore, we anticipate that DLKPAR could yield reliable K(PAR) values from ocean color remote sensing, providing an accurate estimation of visible light attenuation in the upper ocean and facilitating biogeochemical cycle research.
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http://dx.doi.org/10.1364/OE.499743 | DOI Listing |
Drug Deliv Transl Res
January 2025
Kinimmune, Inc. St. Louis, 63141, Missouri, USA.
PD-L1/PD-1 checkpoint inhibitors (CPIs) are mainstream agents for cancer immunotherapy, but the prognosis is unsatisfactory in solid tumor patients lacking preexisting T-cell reactivity. Adjunct therapy strategies including the intratumoral administration of immunostimulants aim to address this limitation. CpG oligodeoxynucleotides (ODNs), TLR9 agonists that can potentiate adaptive immunity, have been widely investigated to tackle PD-L1/PD-1 resistance, but clinical success has been hindered by inconsistent efficacy and immune-related toxicities caused by systemic exposure.
View Article and Find Full Text PDFNeurosurgery
January 2025
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Background And Objectives: Understanding and managing seizure activity is crucial in neuro-oncology, especially for highly epileptogenic lesions like isocitrate dehydrogenase (IDH)-mutant gliomas. Advanced MRI techniques such as diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) have been used to describe microstructural changes associated with epilepsy. However, their role in tumor-related epilepsy (TRE) remains unclear.
View Article and Find Full Text PDFA key contribution to X-ray dark-field (XDF) contrast is the diffusion of X-rays by sample structures smaller than the imaging system's spatial resolution; this is related to position-dependent small-angle X-ray scattering. However, some experimental XDF techniques have reported that XDF contrast is also generated by resolvable sample edges. Speckle-based X-ray imaging (SBXI) extracts the XDF by analyzing sample-imposed changes to a reference speckle pattern's visibility.
View Article and Find Full Text PDFNowadays, spaceborne LiDAR technology, particularly ICESat-2, has become a transformative tool in marine environmental research. Unlike traditional passive optical remote sensing methods, ICESat-2 offers detailed vertical structure mapping of oceanic optical properties. Despite the potential of ICESat-2 for observing the optical vertical structure, its application in the East China Sea with complex hydrological conditions and dynamic ecosystems remains limited.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
University of Colorado, Anschutz Medical Campus School of Medicine| Translational research laboratory of Red Blood Cell Diseases and Hypoxia related illnesses| Cardiovascular Pulmonary Research (CVP) group, Pediatrics. Electronic address:
Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and extravasation of hemoglobin (Hb) into the lung adventitial spaces, where it is linked to nitric oxide depletion, oxidative stress, inflammation, and tissue hypoxia, which collectively drive SCD-PH. Here, we tested the hypothesis that intrapulmonary delivery of hemopexin (Hpx) to the deep lung is effective at scavenging heme-iron and attenuating the progression of SCD-PH.
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