Oxytocin (OXT), produced and secreted in the paraventricular nucleus and supraoptic nucleus of magnocellular and parvocellular neurons. The diverse presence and activity of oxytocin suggests a potential for this neuropeptide in the pathogenesis and treatment of stress-related neuropsychiatric disorders (anxiety, depression and post-traumatic stress disorder (PTSD)). For a more comprehensive understanding of the mechanism of OXT's anti-stress action, the signaling cascade of OXT binding to targeting stress were summarized. Then the advance of OXT treatment in depression, anxiety, PTSD and the major projection region of OXT neuron were discussed. Further, the efficacy of endogenous and exogenous OXT in stress responses were highlighted in this review. To augment the level of OXT in stress-related neuropsychiatric disorders, current biological strategies were summarized to shed a light on the treatment of stress-induced psychiatric disorders. We also conclude some of the major puzzles in the therapeutic uses of OXT in stress-related neuropsychiatric disorders. Although some questions remain to be resolved, OXT has an enormous potential therapeutic use as a hormone that regulates stress responses.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683256 | PMC |
| http://dx.doi.org/10.1186/s13578-023-01173-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Perineuronal Nets in Syrian Hamsters: Anatomical Localization, Sex Differences, Diurnal Variation, and Response to Social Stress.
Brain Behav
December 2024
Neuroscience Institute, Georgia State University, Atlanta, Georgia, USA.
Purpose: Perineuronal nets (PNNs) are extracellular matrix proteoglycans surrounding neurons and glia. It has been suggested that PNNs are involved in the pathophysiology of multiple CNS illnesses, including stress-related neuropsychiatric disorders like schizophrenia, major depressive disorder, and anxiety disorders.
Method: Before examining the putative role of PNNs in stress-related responses, we described for the first time the anatomical distribution in Syrian hamsters (Mesocricetus auratus), an excellent model organism for studying social stress and circadian rhythms.
Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications.
Adv Sci (Weinh)
December 2024
Huck Institutes of the Life Sciences, The Pennsylvania State University, State College, PA, 16802, USA.
Article Synopsis
- Most wearable biosensors currently focus on detecting physical stress markers, but they lack the precision required for accurate diagnosis or prevention of psychological issues.
- Wearable biochemical sensors are an emerging technology with potential, particularly those that can measure cortisol, but they still face specificity challenges.
- The review highlights the need for multiplex wearable sensors that can monitor multiple stress-related biochemical markers simultaneously to better understand the links between psychological stress and neuropsychiatric conditions.
Mechanistic insights regarding neuropsychiatric and neuropathologic impacts of air pollution.
Crit Rev Toxicol
November 2024
Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Air pollution is a significant environmental health risk for urban areas and developing countries. Air pollution may contribute to the incidence of cardiopulmonary and metabolic diseases. Evidence also points to the role of air pollution in worsening or developing neurological and neuropsychiatric conditions.
View Article and Find Full Text PDFCannabidiol inhibits transient receptor potential canonical 4 and modulates excitability of pyramidal neurons in mPFC.
Front Pharmacol
November 2024
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.
Article Synopsis
- - Cannabidiol (CBD), a non-psychoactive compound from cannabis, shows potential in treating various central nervous system disorders like epilepsy and chronic pain, but its exact pharmacological mechanisms remain unclear.
- - This study identified the transient receptor potential canonical 4 (TRPC4) channel as a new target for CBD, demonstrating that CBD can inhibit TRPC4, affecting neuronal excitability in the medial prefrontal cortex.
- - Using whole-cell electrophysiology, researchers found that CBD inhibits the TRPC4 channel's activity, particularly in response to epinephrine, suggesting CBD may reduce neuron excitability by acting on TRPC4 channels.
Elevated neuron specific enolase levels in post-traumatic stress disorder.
Eur J Pediatr
November 2024
Department of Child and Adolescent Psychiatry, Ankara Yıldırım Beyazıt University Yenimahalle Research and Training Hospital, Ankara, Turkey.
Article Synopsis
- The study investigates neuron-specific enolase (NSE) levels in adolescents diagnosed with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), comparing them to healthy controls.
- Blood samples from 43 PTSD patients, 43 MDD patients, and 40 healthy controls revealed that NSE levels were significantly higher in the PTSD group.
- The results suggest that elevated NSE could serve as a potential biomarker for PTSD, indicating stress-related neuronal damage and differentiating it from MDD and healthy individuals.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!