This study aimed to fabricate and characterize the Ca-alginate films functionalized by incorporating zein nanoparticles containing cinnamaldehyde (CA). The zein nanoparticles were coated with Na-caseinate (CN) to inhibit the precipitation of zein in the alginate solution. Afterward, the physical, mechanical, morphological, and barrier properties of the nanocomposite films were evaluated. The particle sizes of different zein nanoparticles (with/without CA and CN) ranged between 43.58 and 251.66 nm. The addition of free CA, zein, and CN nanoparticles significantly increased the thickness, opacity, thermal stability, and water contact angle and improved the mechanical properties of the films. The water vapor permeability was not affected but the antimicrobial activity was improved on fresh-cut apples. The lightness of nanocomposite films decreased and the yellowness and greenness increased. According to SEM and AFM images, a dense and organized interlayer arrangement with a rougher surface was detected in the nanocomposite films. FTIR analysis showed that no new interactions were formed between the Ca-alginate and zein/CN nanoparticles. An excellent sustained CA release into the water was observed for the CA/zein nanoparticles-loaded alginate films. Overall, the results showed that Ca-alginate nanocomposite films of zein nanoparticles have good potential to carry hydrophobic bioactive compounds for specific pharmaceutical and food applications.
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http://dx.doi.org/10.1016/j.ijbiomac.2023.128456 | DOI Listing |
J Mycol Med
January 2025
Mycology Laboratory, School of Pharmacy, Midwestern Paraná State University, UNICENTRO, PR, Brazil. Electronic address:
Bloodstream infection in neonates is a complicated disease and presents a major challenge both in diagnosis and in therapeutic intervention. The focus of the present study was to investigate the incidence, the species distribution and the risk factors associated with mortality of bloodstream infections in a neonatal intensive care unit (NICU) and evaluating the antifungal susceptibility of traditional antifungal drugs and three nanoparticle-based drug delivery systems based on nanoparticles. A total of 458 patients were evaluated, and 9.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Food Science and Technology, South China Agricultural University, Guangzhou 510642, China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China; State Key Laboratory of Food Science and Resources, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China. Electronic address:
In this paper, zein-carboxymethyl starch (CMS) nanoparticles were prepared by antisolvent precipitation method to improve the stability of rutin (RT). The encapsulation efficiency, loading capacity, oxidation resistance, structural properties were evaluated. The results showed that electrostatic, hydrogen bond and hydrophobic interaction were the main driving forces for the formation of nanoparticles.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Pharmaceutical Nanotechnology Research Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India. Electronic address:
The objective of this work was to explore the Teriflunomide (TFM) -loaded chondroitin sulfate hybridized zein nanoparticles (TZCNPs) for the treatment of triple-negative breast cancer (TNBC). The particle size, PDI and %EE of optimized TZCNPs was found 208.7 ± 7.
View Article and Find Full Text PDFToxics
January 2025
Department of Chemical Engineering, Faculty of Sciences, University of Granada, Campus Fuente Nueva s/n, 18071 Granada, Spain.
Surfactants play a crucial role in various industrial applications, including detergents and personal care products. However, their widespread use raises concerns due to their potential environmental impact and health risks, particularly in aquatic ecosystems, where they can disrupt the balance of marine life and accumulate in water sources, posing challenges to sustainable development. This study investigates the environmental and health implications of anionic and nonionic surfactants, focusing on their toxicity, biodegradation, and skin irritation potential profiles, especially when combined with silica nanoparticles.
View Article and Find Full Text PDFFood Res Int
February 2025
School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo 255049, Shandong, PR China. Electronic address:
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