AI Article Synopsis
- - Lyme disease is caused by a type of bacteria called Borrelia burgdorferi, which enters the human body through infected tick bites and has surface proteins that help it survive and spread in hosts.
- - This study focuses on a specific outer surface protein called BB0158, which is part of a gene family consisting of five proteins, and has been analyzed to understand its 3D structure and role in the bacteria.
- - The research reveals that BB0158 forms a unique structure known as a domain-swapped dimer, providing insights into the proteins of Borrelia burgdorferi that are essential for invoking Lyme disease.
Article Abstract
Lyme disease, or also known as Lyme borreliosis, is caused by the spirochetes belonging to the Borrelia burgdorferi sensu lato complex, which can enter the human body following the bite of an infected tick. Many membrane lipid-bound proteins, also known as lipoproteins, are located on the surface of B. burgdorferi sensu lato and play a crucial role in the spirochete to interact with its environment, whether in ticks or mammals. Since the spirochete needs to perform various tasks, such as resisting the host's immune system or spreading throughout the organism, it is not surprising that numerous surface proteins have been found to be essential for B. burgdorferi sensu lato complex bacteria in causing Lyme disease. In this study, we have determined (at 2.4 Å resolution) and characterized the 3D structure of BB0158, one of the few chromosomally encoded outer surface proteins from B. burgdorferi sensu stricto. BB0158 belongs to the paralogous gene family 44 (PFam44), consisting of four other members (BB0159, BBA04, BBE09 and BBK52). The characterization of BB0158, which appears to form a domain-swapped dimer, in conjunction with the characterization of the corresponding PFam44 members, certainly contribute to our understanding of B. burgdorferi sensu stricto proteins.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ttbdis.2023.102287 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence of Borrelia burgdorferi sensu lato infection in the Czech Republic.
Int J Med Microbiol
January 2025
Global Vaccines, and Anti-infectives Medical Affairs, Pfizer Inc., 1 Portland Street, Cambridge, MA 02139, USA. Electronic address:
Introduction: Lyme borreliosis (LB), an infection caused by Borrelia burgdorferi sensu lato (Bbsl), is the most common tick-borne disease in Europe. To further characterize the LB burden in the Czech Republic, we conducted a seroprevalence study and estimated the incidence of symptomatic Bbsl infections.
Methods: Anti-Bbsl IgM and IgG antibodies were detected in sera collected from the adult population in 2011 -2012 by enzyme-linked immunosorbent assay and immunoblot tests at the National Reference Laboratory.
Presence of Borrelia Spirochetes in White Stork (), White-Tailed Eagle (), and Eastern Imperial Eagle (): Hospitalized in a Wild Bird Hospital and Sanctuary (Hortobágy, Hungary).
Animals (Basel)
December 2024
Department of Animal Science, Albert Kázmér Faculty of Agricultural and Food Sciences, Széchenyi István University, 9200 Mosonmagyaróvár, Hungary.
Wild birds across the globe can carry the causative agent of avian borreliosis, , and that of human Lyme borreliosis, sensu lato in the ticks attached to them. Currently, only limited proof exists for the presence of these pathogens in samples taken from living wild birds, carried by the birds as a reservoir, without symptoms. We investigated blood samples of large-bodied wild birds admitted to a bird hospital, where basic clinical symptoms were recorded.
View Article and Find Full Text PDFAcquisition of Borrelia burgdorferi sensu stricto (Spirochaetales: Spirochaetaceae) by Haemaphysalis longicornis (Acari: Ixodidae) nymphs during interrupted feeding.
J Med Entomol
January 2025
Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
A previous laboratory study using Haemaphysalis longicornis Neumann (Acari: Ixodidae) ticks of North American origin showed that larvae could acquire the Lyme disease spirochete, Borrelia burgdorferi sensu stricto (s.s.) (Spirochaetales: Spirochaetaceae) while feeding to completion on infected mice.
View Article and Find Full Text PDFTwo decades of research on sensu lato in questing ticks in Slovakia.
Front Cell Infect Microbiol
December 2024
Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia.
Introduction: In Europe sensu lato (s.l.), the causative agent of Lyme borreliosis is transmitted by the castor bean tick, .
View Article and Find Full Text PDFA comparative study evaluating three line immunoassays available for serodiagnosis of equine Lyme borreliosis: Detection of Borrelia burgdorferi sensu lato-specific antibodies in serum samples of vaccinated and non-vaccinated horses.
PLoS One
December 2024
Faculty of Veterinary Medicine, Department of Veterinary Sciences, Institute for Infectious Diseases and Zoonoses, Chair of Bacteriology and Mycology, Ludwig-Maximilians-Universität Munich, Oberschleißheim, Bavaria, Germany.
Diagnosis of equine Lyme borreliosis (LB), an infection caused by members of the Borrelia burgdorferi sensu lato complex (Bbsl), is challenging due to the nonspecific clinical signs of the disease and due to the variety of non-standardized serological tests. Specific vaccine-induced antibodies against LB, providing an effective protection against the infection, complicate the issue further. The standard for the detection of specific antibodies against Bbsl is a two-tier test system based on an enzyme-linked immunosorbent assay (ELISA) or indirect fluorescent antibody test (IFA) for antibody screening combined with a qualitative, highly specific immunoassay (e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!