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Acquired Epidermodysplasia Verruciformis With HPV5 RNA Expression Using RNA Chromogenic In Situ Hybridization.
J Cutan Pathol
November 2024
Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Acquired epidermodysplasia verruciformis is a rare condition, secondary to a state of acquired immunosuppression and is characterized by a susceptibility to infection by human papillomavirus of the beta genus, which carries an increased risk of developing non-melanoma skin cancer. We report the case of a 39-year-old woman receiving a kidney transplant, treated with prednisone and tacrolimus, who after starting immunosuppressive therapy developed papules and warty plaques in the inguinal region. A skin biopsy was performed that was consistent with epidermodysplasia verruciformis, so it was decided to adjust immunosuppressive therapy to everolimus, which achieved a reduction in lesions.
View Article and Find Full Text PDFAcquired epidermodysplasia verruciformis syndrome in HIV-infected patients: a systematic review.
Arch Dermatol Res
July 2024
Universidad Rey Juan Carlos, Madrid, Spain.
Article Synopsis
- * A systematic review identified 80 relevant studies out of 126 searched, highlighting that the diagnosis of AEV can take an average of 7 years and lesions remain unchanged with standard HIV treatments, making management challenging.
- * Current treatments for AEV, such as glycolic acid and imiquimod, show limited effectiveness, and while the risk of certain skin cancers is lower in A
Epidermodysplasia verruciformis-associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features.
Virchows Arch
March 2024
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Article Synopsis
- Most tumors result from genetic changes, but some are linked to viral infections like HPV, which can lead to specific skin conditions.
- Epidermodysplasia verruciformis (EDV) is a rare HPV infection characterized by unique histological features and specific HPV subtypes.
- The study discusses a particular type of EDV-related tumor found in two patients, highlighting consistent features and suggesting it could be a unique, reproducible form of skin tumor.
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