AI Article Synopsis
- The use of deuterium and tritium labels has become crucial across various research fields, with hydrogen isotope exchange (HIE) allowing for the introduction of these isotopes in later stages of compound preparation.
- Recent advancements in HIE highlight the role of alkali-metal bases as effective catalysts, alongside the established use of transition metal catalysis, showcasing their synthetic potential.
- The minireview explores the latest developments, challenges, and mechanisms associated with alkali-metal bases in HIE, categorizing findings based on the specific isotope source and discussing their advantages and limitations.
Article Abstract
The preparation of compounds labelled with deuterium or tritium has become an essential tool in a range of research fields. Hydrogen isotope exchange (HIE) offers direct access to said compounds, introducing these isotopes in a late stage. Even though the field has rapidly advanced with the use of transition metal catalysis, alkali-metal bases, used as catalysts or under stoichiometric conditions, have also emerged as a viable alternative. In this minireview we describe the latest advances in the use of alkali-metal bases in HIE processes, showcasing their synthetic potential as well as current challenges in the field. It is divided in different sections based on the isotope source used, emphasizing their benefits, disadvantages and limitations. The influence on the choice of alkali-metal in these processes as well as their possible mechanistic pathways are also discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465149 | PMC |
| http://dx.doi.org/10.1039/d3cy00825h | DOI Listing |
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