The relationship between scores on the Framingham Type A Scale (FTAS) and angiographic severity of coronary artery disease (CAD) was examined in a sample of 50 patients undergoing diagnostic cardiac catheterization. Age and family history of coronary heart disease (CHD) were positively related to CAD severity. Contrary to prediction, the FTAS demonstrated a non-significant, inverse relationship with CAD. However, FTAS-defined Type As with at least some CAD were younger than Type Bs with CAD. This inverse relationship between FTAS scores and age was not found in patients without CAD. Thus, though the FTAS was related to a younger clinical presentation requiring catheterization, it was not associated with the severity of CAD.
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BMC Endocr Disord
January 2025
Family medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 454, Göteborg, 40530, Sweden.
Background: Endogenous sex hormones in postmenopausal women have been associated with risk of cardiovascular diseases. The aim of this study was to determine the association between endogenous sex hormones and the revised Framingham Stroke Risk Profile (rFSRP) in postmenopausal women.
Methods: This is an observational cross-sectional study on the Vara-Skövde cohort, a Swedish population-based study for longitudinal surveillance of the development and progress of type 2 diabetes and hypertension.
medRxiv
January 2025
Center for Advanced Orthopedic Studies, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Pathologic vertebral fractures (PVF) are common and serious complications in patients with metastatic lesions affecting the spine. Accurate assessment of cancer patients' PVF risk is an unmet clinical need. Load-to-strength ratios (LSRs) evaluated in vivo by estimating vertebral loading from biomechanical modeling and strength from computed tomography imaging (CT) have been associated with osteoporotic vertebral fractures in older adults.
View Article and Find Full Text PDFGenet Epidemiol
January 2025
Department of Biostatistics, University of Washington, Seattle, Washington, USA.
Integrating multi-omics data may help researchers understand the genetic underpinnings of complex traits and diseases. However, the best ways to integrate multi-omics data and use them to address pressing scientific questions remain a challenge. One important and topical problem is how to assess the aggregate effect of multiple genomic data types (e.
View Article and Find Full Text PDFNutrients
December 2024
Preventive Medicine and Epidemiology, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
Objectives: Given the considerable discrepancy in the literature regarding dietary protein and glucose homeostasis, we examined the prospective association between protein intake (total, animal, plant) and risk of type 2 diabetes mellitus or impaired fasting glucose (IFG). We also examined whether these associations differed by sex, body weight, or other risk factors.
Methods: We included 1423 subjects, aged ≥ 30 years, in the Framingham Offspring Study cohort.
J Family Med Prim Care
December 2024
Senior Resident, Department of General Medicine, Dr. Baba Saheb Ambedkar Hospital and Medical College, Rohini, New Delhi, India.
Background: Diabetic population are at an increased risk of developing dyslipidemia and other cardiovascular complications. The study was performed to evaluate the lipid profile parameter in the diabetic population among the ethnic tribal community of Tripura and calculate the risk of cardiovascular events. The tribal community was chosen as the study population because their lifestyle, food habits, culture and housing practices are different from people living on the plains.
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