AI Article Synopsis
- An 11-year-old Persian cat underwent surgery to remove her ovaries and uterus due to irregular thickening and swelling of the uterine wall.
- The examination revealed that the swelling was caused by multiple nodules made of abnormal cells that had infiltrated the surrounding tissue.
- The tumor was diagnosed as endometrial stromal sarcoma (ESS), with characteristics similar to high-grade ESS found in humans, based on specific cell markers and tissue behavior.
Article Abstract
An 11-year-old female Persian cat underwent ovariohysterectomy due to dilation of the uterine cavity with irregular thickening of the wall. Macroscopically, the middle and distal regions of the left uterine horn were swollen and the uterine wall was irregularly thickened due to the development of multiple coalescent, variably sized nodules. Microscopically, the nodules had originated in the endometrium and were composed of round to polygonal neoplastic cells arranged in dense sheets or ill-defined fascicles. The neoplastic cells had locally invaded the myometrium and reached the subserosa, with lymphovascular invasion. Immunohistochemically, the neoplastic cell population was partially positive for CD10, an established marker of endometrial stromal sarcoma (ESS) in humans, with focal and diffuse nuclear immunopositivity for oestrogen and progesterone receptors and immunonegativity for desmin and α-smooth muscle actin. Based on these findings, the uterine tumour was diagnosed as ESS and was considered to correspond morphologically to high-grade ESS in humans.
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| http://dx.doi.org/10.1016/j.jcpa.2023.10.011 | DOI Listing |
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