Background: Trajectories of stratum corneum (SC) lipid subclasses and their associations with infant atopic dermatitis (AD) are unclear. This study aimed to quantify the trajectories of 15 SC subclasses and carbon chain lengths and their associations with AD within 12 months.
Methods: In total, 213 newborns were enrolled at birth with nonlesional skin samples collected from the inner forearm at birth, 42 days, 3, 6, and 12 months, respectively. Lesional skin samples were collected from 120 AD patients at clinic with the disease onset within the first year of life. Mass spectrometry was applied to assess relative contents of 12 ceramide (CER), three free fatty acid (FFA) subclasses, and average carbon chain length (CCL). AD incident within 1 year old was diagnosed by dermatologists according to UK criteria.
Results: Sixty-four (30.0%) cases of ADs occurred in the cohort. All SC lipid subclasses and CCLs, but EOP varied significantly during the first year. AD infants showed lower NP but higher NS, NH, AP, hydroxy FFA, and CCL of FFAs compared with nonaffected infants. After normalization by age, the differences remained and were more pronounced in lesional skin of clinical AD infants compared with non-ADs. NS, NH, and CCL of FFAs in lesional skin of AD infants showed positive and significant correlations with the levels of transepidermal water loss at 3 month; some evidence supports a negative correlation for NP.
Conclusions: We provide an overview of developmental trajectories of 15 CER and FFA subclasses across the first year of healthy infants and a link between the imbalance of some subclasses with the development of AD.
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http://dx.doi.org/10.1111/pai.14045 | DOI Listing |
J Med Biochem
September 2024
University of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia.
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December 2024
Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:
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November 2024
Sam Farr United States Crop Improvement and Protection Research Center, Agricultural Research Service, U.S. Department of Agriculture, Salinas, CA 93905, USA.
Lettuce ( L.) is a popular leafy vegetable valued for its dietary fiber, antioxidants, and beneficial vitamins. This study presents a comprehensive spatio-temporal analysis of the lettuce metabolome, revealing complex dynamics in metabolite accumulation influenced by plant age, leaf position, proximodistal distribution within a leaf, and head closure.
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December 2024
Centre for Metabolomics Research (CMR), Department of Biochemistry, Cell, and Systems Biology, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Introduction: Outside of case-control settings, ethnicity specific changes in the human metabolome are understudied especially in community dwelling, ageing men. Characterising serum for age and ethnicity specific features can enable tailored therapeutics research and improve our understanding of the interplay between age, ethnicity, and metabolism in global populations.
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Water Res
December 2024
College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address:
Eutrophication has emerged as a significant environmental problem for global lakes. As an essential carrier of nutrients, particulate organic matter (POM) plays a vital role in the eutrophication process of these aquatic systems. In this study, POM from seven lakes with different trophic states in the middle and lower reaches of the Yangtze River (China) was characterized using carbon and nitrogen stable isotopes and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).
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