AI Article Synopsis
- The study explores the diverse ways bacteria acquire and regulate iron, highlighting its link to cellulose utilization.
- Two out of the four identified TonB genes in the bacteria show functional redundancy, playing a vital role in transporting iron via siderophores.
- Uniquely, these TonB genes are not regulated by iron levels, likely because they are also crucial for using cellulose as a carbon source, resulting in their expression even when iron is abundant.
Article Abstract
This study highlights diversity in iron acquisition and regulation in bacteria. The mechanisms of iron acquisition and its regulation in , as well as its connection to cellulose utilization, a hallmark phenotype of , expand the paradigm of bacterial iron acquisition. Two of the four TonB genes identified in exhibit functional redundancy and play a crucial role in siderophore-mediated iron transport. Unlike typical TonB genes in bacteria, none of the TonB genes in are clearly iron regulated. This unusual regulation could be explained by another important finding in this study, namely, that the two TonB genes involved in iron transport are also essential for cellulose utilization as a carbon source, leading to the expression of TonB genes even under iron-rich conditions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734418 | PMC |
| http://dx.doi.org/10.1128/aem.00744-23 | DOI Listing |
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