AI Article Synopsis
- The study focused on characterizing potential phages of Saccharibacteria, which are important due to their role in human oral diseases.
- It also investigated phages associated with Gracilibacteria and Absconditabacteria, two unique groups that utilize a different genetic code.
- The results revealed phages targeted by various bacteria, providing insights into phage replication strategies and their implications for phage therapy aimed at altering microbiomes with these lesser-known bacteria.
Article Abstract
Here, we profiled putative phages of Saccharibacteria, which are of particular importance as Saccharibacteria influence some human oral diseases. We additionally profiled putative phages of Gracilibacteria and Absconditabacteria, two Candidate Phyla Radiation (CPR) lineages of interest given their use of an alternative genetic code. Among the phages identified in this study, some are targeted by spacers from both CPR and non-CPR bacteria and others by both bacteria that use the standard genetic code as well as bacteria that use an alternative genetic code. These findings represent new insights into possible phage replication strategies and have relevance for phage therapies that seek to manipulate microbiomes containing CPR bacteria.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746230 | PMC |
| http://dx.doi.org/10.1128/mbio.01766-23 | DOI Listing |
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