AI Article Synopsis
- Osteomyelitis, a hard-to-treat bone infection, is tough to fix using light because it can't reach deep enough into the tissue.
- Researchers created special tiny structures called Cu/C/FeO-COOH that can capture and kill bacteria when exposed to microwaves.
- This new method is promising for treating infections like Staphylococcus aureus by using heat and a special kind of therapy with copper, making it easier to fight deep tissue infections.
Article Abstract
Osteomyelitis caused by deep tissue infections is difficult to cure through phototherapy due to the poor penetration depth of the light. Herein, Cu/C/FeO-COOH nanorod composites (Cu/C/FeO-COOH) with nanoscale tip convex structures are successfully fabricated as a microwave-responsive smart bacteria-capture-killing vector. Cu/C/FeO-COOH exhibited excellent magnetic targeting and bacteria-capturing ability due to its magnetism and high selectivity affinity to the amino groups on the surface of Staphylococcus aureus (S. aureus). Under microwave irradiation, Cu/C/FeO-COOH efficiently treated S. aureus-infected osteomyelitis through the synergistic effects of microwave thermal therapy, microwave dynamic therapy, and copper ion therapy. It is calculated the electric field intensity in various regions of Cu/C/FeO-COOH under microwave irradiation, demonstrating that it obtained the highest electric field intensity on the surface of copper nanoparticles of Cu/C/FeO-COOH due to its high-curvature tips and metallic properties. This led to copper nanoparticles attracted more charged particles compared with other areas in Cu/C/FeO-COOH. These charges are easier to escape from the high curvature surface of Cu/C/FeO-COOH, and captured by adsorbed oxygen, resulting in the generation of reactive oxygen species. The Cu/C/FeO-COOH designed in this study is expected to provide insight into the treatment of deep tissue infections under the irradiation of microwave.
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| http://dx.doi.org/10.1002/smll.202307406 | DOI Listing |
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