AI Article Synopsis
- - The study examines the effects of a Gram-negative bacteria, commonly found in some beverages, on inflammation and gut health in a mouse model of colitis induced by DSS.
- - Results showed that this bacteria reduces symptoms of colitis, improves tissue health, and enhances gut microbiota balance by promoting beneficial microbial growth while suppressing harmful ones.
- - Additionally, it appears to boost the immune response by increasing certain protective genes and lowering inflammatory cytokines, suggesting its potential as a probiotic for bowel diseases.
Article Abstract
, a Gram-negative bacteria observed in some popular beverages, is considered safe and has been studied for its potential therapeutic benefits. In this study, we explored its effects on the inflammatory process, tissue integrity, differential gene expression, and microbiota composition in an experimental dextran sulfate sodium (DSS)-induced colitis model in mice. As a result, alleviated the symptoms caused by DSS administration, as indicated by reduced weight loss, disease activity index, a significant reduction in the colon weight/length ratio, and histopathological improvement. Also, could restore the mucosal barrier as well as increase the expression of and genes. An analysis of 16S rRNA sequences showed that alters gut microbiota, increasing abundance and decreasing . Furthermore, seems to be involved in potentiating a regulatory phenotype by inducing immunomodulatory genes like , , , and and reducing the relative mRNA expression of proinflammatory cytokines , , and . Our data suggest that could alleviate disease progression and be considered a possible probiotic adjuvant for pathologies of the bowel.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672878 | PMC |
| http://dx.doi.org/10.3390/microorganisms11112793 | DOI Listing |
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