Dysbiosis by Eradication of Infection Associated with Follicular Gastropathy and Pangastropathy.

Dysbiosis plays an important role in the development of bacterial infections in the gastric mucosa, particularly . The international guidelines for the treatment of infections suggest standard triple therapy (STT). Nevertheless, because of the increasing resistance rates to clarithromycin, metronidazole has been widely considered in several countries. Unfortunately, the non-justified administration of antibiotics induces dysbiosis in the target organ. We characterized the gastric microbiota of patients diagnosed with follicular gastropathy and pangastropathy attributed to infection, before and after the administration of STT with metronidazole. Dominant relative abundances of were observed in pre-treatment patients, whereas was observed at <11%, suggesting the multifactor property of the disease. The correlation of and with gastric infectious diseases was also evaluated using quantitative real-time polymerase chain reaction. The dominance of over was observed in gastritis, gastropathies, and non-significant histological alterations. None of the microorganisms were detected in the intestinal metaplasia. Post-treatment alterations revealed an increase in the relative abundances of , , and . Non- gastrointestinal bacteria can be associated with the initiation and development of gastric diseases, such as pathobiont .