This article highlights recent developments of SPECT and PET diagnostic imaging surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the rationale for using imaging surrogates to improve diagnostic-scan accuracy and facilitate research, and the properties an imaging-surrogate candidate should possess. It evaluates the strengths and limitations of each potential imaging surrogate. Thirteen surrogates for TAT are explored: La, La, Ce/La, and Ac for Ac TAT; Pb for Pb TAT; Ba for Ra and Ra TAT; I, I, I and At for At TAT; Ce/La for Th TAT; and Tb and Tb for Tb TAT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10674391 | PMC |
| http://dx.doi.org/10.3390/ph16111622 | DOI Listing |
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