AI Article Synopsis
- Metabolic dysfunction-associated steatotic fatty liver disease (MASLD) is a growing global health concern linked to liver disease, driven by factors like mitochondrial dysfunction, lipid metabolism issues, inflammation, and oxidative stress.
- Changes in diet and lifestyle, particularly through natural compounds, can positively influence these mechanisms and promote better liver health by altering epigenetic factors and mitochondrial functions.
- This review discusses recent research on how bioactive compounds affect mitochondria in the context of MASLD, aiming to improve our understanding and treatment of the disease through insights into epigenetic modifications.
Article Abstract
Metabolic dysfunction-associated steatotic fatty liver disease (MASLD), a novel definition for NAFLD, represents one of the most common causes of liver disease, and its incidence is increasing worldwide. It is characterized by a complex etiopathogenesis in which mitochondrial dysfunction exerts a pivotal role together with alteration of lipid metabolism, inflammation, and oxidative stress. Nutrients and bioactive compounds can influence such mechanisms so that changes in diet and lifestyle are regarded as important treatment strategies. Notably, natural compounds can exert their influence through changes of the epigenetic landscape, overall resulting in rewiring of molecular networks involved in cell and tissue homeostasis. Considering such information, the present review aims at providing evidence of epigenetic modifications occurring at mitochondria in response to natural and bioactive compounds in the context of liver (dys)function. For this purpose, recent studies reporting effects of compounds on mitochondria in the context of NAFLD/MASLD, as well as research showing alteration of DNA methylation and non-coding RNAs-related circuits occurring at liver mitochondria, will be illustrated. Overall, the present review will highlight the importance of understanding the bioactive compounds-dependent epigenetic modulation of mitochondria for improving the knowledge of MASLD and identifying biomarkers to be employed for effective preventative strategies or treatment protocols.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675587 | PMC |
| http://dx.doi.org/10.3390/nu15224757 | DOI Listing |
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