AI Article Synopsis
- Oral mucositis negatively impacts the quality of life for hematologic cancer patients undergoing stem cell transplants, yet there's limited use of low-level laser therapy (LLLT) in Japan for prevention.
- This study compared 21 patients treated with LLLT to a historical control group of 96 patients and found a significantly lower rate of severe mucositis (23.8% vs. 64.6%).
- Results suggest LLLT is effective in preventing severe oral mucositis in Japanese patients, highlighting the need for its wider clinical adoption in Japan.
Article Abstract
Oral mucositis significantly affects the quality of life in hematologic cancer patients undergoing hematopoietic stem cell transplantation. Despite global evidence supporting the efficacy of low-level laser therapy (LLLT) for mucositis prevention, its clinical adoption in Japan is limited. This study aimed to fill this gap by evaluating the safety and efficacy of LLLT in a Japanese patient population. In a single-group, non-blinded, exploratory trial, we compared 21 LLLT-treated patients against a historical control of 96 patients. The primary endpoint was the incidence of Grade ≥ 2 mucositis, based on NCI-CTCAE ver. 4.0. The LLLT group showed a significantly lower incidence of Grade ≥ 2 mucositis (23.8%) compared to the control group (64.6%) ( = 0.0006). Furthermore, Grade ≥ 2 mucositis correlated with increased oral dryness and longer hospital stays. Our study confirms the efficacy of LLLT in reducing the onset of severe oral mucositis among Japanese hematologic cancer patients, advocating for its clinical introduction as a preventive measure in Japan.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672422 | PMC |
| http://dx.doi.org/10.3390/jpm13111603 | DOI Listing |
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