AI Article Synopsis
- Interstitial lung disease and airway disease are serious complications of rheumatoid arthritis, leading to a poor prognosis among affected individuals.
- This study examined the genetic factors linked to these lung diseases in Japanese RA patients, specifically focusing on two single nucleotide variants (rs2736100 and rs1278769).
- Findings indicated that rs2736100 is associated with increased susceptibility to airway disease, while rs1278769 is linked to nonspecific interstitial pneumonia in older patients, marking a significant step in understanding genetic risks in RA-related lung issues.
Article Abstract
Interstitial lung disease and airway disease (AD) are often complicated with rheumatoid arthritis (RA) and have a poor prognosis. Several studies reported genetic associations with interstitial lung disease in RA. However, few genetic studies have examined the susceptibility to AD in RA patients. Here, we investigated whether single nucleotide variants susceptible to idiopathic pulmonary fibrosis might be associated with interstitial lung disease or AD in Japanese RA patients. Genotyping of rs2736100 [C/A] in and rs1278769 [G/A] in was conducted in 98 RA patients with usual interstitial pneumonia, 120 with nonspecific interstitial pneumonia (NSIP), 227 with AD, and 422 without chronic lung disease using TaqMan assays. An association with AD in RA was found for rs2736100 ( = 0.0043, Pc = 0.0129, odds ratio [OR] 1.40, 95% confidence interval [CI] 1.11-1.77). rs1278769 was significantly associated with NSIP in older RA patients (>65 years, = 0.0010, OR 2.15, 95% CI 1.35-3.40). This study first reported an association of rs2736100 with AD in RA patients and rs1278769 with NSIP in older RA patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10671651 | PMC |
| http://dx.doi.org/10.3390/genes14112084 | DOI Listing |
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