AI Article Synopsis
- - The process of bone regeneration involves several factors, including inflammation, tissue interactions, and progenitor cells, with complications in trauma cases often leading to delayed healing that may require bone grafting, which has drawbacks like donor site morbidity and material availability.
- - Adipose-derived stem cells (ASCs) have shown promise in enhancing bone regeneration; findings indicate that a specific treatment group (C/S) exhibited faster and more effective bone healing compared to others, as measured by radiological assessments and Micro-CT imaging.
- - The study highlights the potential of ADMSCs for clinical applications in treating bone diseases, showing that while newly formed bone differed slightly in density from normal tissue, the overall findings support their use in regenerative medicine and early-stage
Article Abstract
The complex process of bone regeneration is influenced by factors such as inflammatory responses, tissue interactions, and progenitor cells. Currently, multiple traumas can interfere with fracture healing, causing the prolonging or failure of healing. In these cases, bone grafting is the most effective treatment. However, there are several drawbacks, such as morbidity at the donor site and availability of suitable materials. Advantages have been provided in this field by a variety of stem cell types. Adipose-derived stem cells (ASCs) show promise. In the radiological examination of this study, it was confirmed that the C/S group showed faster regeneration than the other groups, and Micro-CT also showed that the degree of bone formation in the defect area was highest in the C/S group. Compared to the control group, the change in cortical bone area in the defect area decreased in the sham group (0.874), while it slightly increased in the C/S group (1.027). An increase in relative vascularity indicates a decrease in overall bone density, but a weak depression filled with fibrous tissue was observed outside the compact bone. It was confirmed that newly formed cortical bone showed a slight difference in bone density compared to surrounding normal bone tissue due to increased distribution of cortical bone. In this study, we investigated the effect of bone regeneration by ADMSCs measured by radiation and pathological effects. These data can ultimately be applied to humans with important clinical applications in various bone diseases, regenerative, and early stages of formative differentiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669612 | PMC |
| http://dx.doi.org/10.3390/bioengineering10111311 | DOI Listing |
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