AI Article Synopsis
- This study explored how the blood flow in the endometrial region can predict pregnancy outcomes in women undergoing hormone replacement therapy-frozen embryo transfer (HRT-FET).
- It involved 292 women and used power Doppler ultrasound to assess blood flow on two critical days: the day of endometrial transformation and the day before embryo transfer.
- The results showed that women who became pregnant had significantly higher endometrial blood flow than those who did not, particularly the day before embryo transfer, suggesting that monitoring blood flow could be a valuable tool for predicting successful pregnancies.
Article Abstract
Background: This study aimed to assess the predictive value of endometrial blood flow branches on pregnancy outcomes after hormone replacement therapy-frozen embryo transfer (HRT-FET).
Methods: This prospective observational study involved 292 reproductive-aged women who underwent endometrial receptivity assessment in a tertiary care academic medical center in southwest China using power Doppler ultrasonography during HRT-FET. Three-dimensional power Doppler ultrasound was performed on the day of endometrial transformation and the day before embryo transfer. The endometrial blood flow branches of the endometrial and subendometrial regions were compared in the non-pregnant and pregnant groups at the two time points mentioned above.
Results: The endometrial blood flow branches were higher in pregnant patients than in non-pregnant patients on the day of endometrial transformation (P = 0.009) and the day before embryo transfer (P = 0.001). Changes in endometrial blood flow pattern and endometrial blood flow branches at the two time points did not differ among the pregnancy outcome samples. After adjusting for age, antral follicles, and embryos transferred, the endometrial blood flow branches on the day before embryo transfer was the independent factor influencing the chance of clinical pregnancy, with an odds ratio of 3.001 (95% confidence interval: 1.448 - 6.219, P = 0.003).
Conclusions: Endometrial blood flow perfusion during the peri-transplantation period of the HRT-FET cycle is a good indicator of pregnancy outcomes, suggesting that valuation of endometrial branches via power Doppler ultrasound is a simple and effective approach for achieving indicator measurements.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668347 | PMC |
| http://dx.doi.org/10.1186/s12958-023-01164-9 | DOI Listing |
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