AI Article Synopsis
- Use of mixed-oil intravenous fat emulsions (MO-IFE) reduces biofilm formation by Candida albicans and lowers the rate of catheter-related bloodstream infections (CR-BSIs) compared to soybean-oil emulsions (SO-IFE).
- Research involved gene analysis of C. albicans in different IFE environments and a 5-year study on pediatric CR-BSI cases to see how IFE choice influenced Candida species distributions.
- Findings suggest that MO-IFE inhibits biofilm and hyphal growth in C. albicans through a UME6-dependent pathway, with a slight increase in non-albicans Candida infections noted, though not statistically significant.
Article Abstract
Background: Use of mixed-oil (MO) intravenous fat emulsion (IFE) was shown to inhibit Candida albicans biofilm formation and overall rate of catheter-related bloodstream infections (CR-BSIs) compared with soybean-oil (SO) IFE). We aimed to delineate this inhibitory mechanism and impact of IFE choice on distribution of fungal CR-BSIs.
Methods: Transcriptional profiling was conducted on C. albicans grown in SO-IFE, MO-IFE, or SO-IFE with capric acid. Overexpression strains of shared down-regulated genes were constructed using a tetracycline-off system to assess hypha and biofilm formation in IFEs. A 5-year retrospective multicenter cohort study was performed to assess differences in CR-BSIs caused by Candida species based on the IFE formulation received in pediatric patients.
Results: Genes significantly down-regulated in MO-IFE and SO-IFE with capric acid included CDC11, HGC1, and UME6. Overexpression of HGC1 or UME6 enabled filamentation in capric acid and MO-IFE. Interestingly, only overexpression of UME6 was sufficient to rescue biofilm growth in MO-IFE. MO-IFE administration was associated with a higher proportion of non-albicans Candida versus C. albicans CR-BSIs (42% vs 33%; odds ratio, 1.22 [95% confidence interval, .46-3.26]).
Conclusions: MO-IFE affects C. albicans biofilm formation and hyphal growth via a UME6-dependent mechanism. A numerical but not statistically significant difference in distribution of Candida spp. among CR-BSIs was observed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10873182 | PMC |
| http://dx.doi.org/10.1093/infdis/jiad527 | DOI Listing |
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