AI Article Synopsis
- The study investigates how vagus nerve stimulation (VNS) affects brain networks and seizure control in patients with drug-resistant epilepsy using stereoelectroencephalography (SEEG).
- It finds that VNS induces a greater spread of desynchronization in the brain, implying that more effective VNS treatment correlates with broader neural changes.
- Future research should examine the link between neural synchronization changes and VNS effectiveness, with potential for using synchronization as a marker for optimizing treatment.
Article Abstract
As the pathophysiological mechanisms of vagus nerve stimulation (VNS) causing individual differences in the vagal ascending network remains unclear, stereoelectroencephalography (SEEG) provides a unique platform to explore the brain networks affected by VNS and helps to understand the anti-seizure mechanism of VNS more comprehensively. This study presents a preliminary exploration of the acute effect of VNS. SEEG signals were collected to assess the acute effect of VNS on neural synchronization in patients with drug-resistant epilepsy, especially in epileptogenic networks. The results show that the better the efficacy of VNS, the wider the spread of desynchronization assessed by weighted phase lag index at a high frequency band caused by VNS. Future studies should focus on the association between the change in synchronization and the efficacy of VNS, exploring the possibility of synchronization as a biomarker for patient screening and parameter programming.
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| http://dx.doi.org/10.1016/j.nec.2023.09.005 | DOI Listing |
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