SARS-CoV-2 breakthrough infections following inactivated vaccine vaccination induce few neutralizing antibodies against the currently emerging Omicron XBB variants.

Virol Sin

Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, 650500, China. Electronic address:

Published: February 2024

AI Article Synopsis

  • People who got sick after getting an inactivated vaccine had very low protection against a newer virus called XBB.
  • If they were infected with the Omicron BA.1 or BA.5 versions, they also had weak protection against XBB.
  • However, getting sick from BA.5 gave a little bit better protection against XBB than getting sick from BA.1.

Article Abstract

• Inactivated vaccine breakthrough infection with ancestral variants induced nearly undetectable nAbs against XBB variants. • Inactivated vaccine breakthrough infection with Omicron BA.1 or BA.5 evoked very weak nAbs against XBB variants. • BA.5 infection induced higher nAbs against XBB variants than BA.1 infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10877414PMC
http://dx.doi.org/10.1016/j.virs.2023.11.007DOI Listing

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