Two-mode squeezed states, which are entangled states with bipartite quantum correlations in continuous-variable systems, are crucial in quantum information processing and metrology. Recently, continuous-variable quantum computing with the vibrational modes of trapped atoms has emerged with significant progress, featuring a high degree of control in hybridizing with spin qubits. Creating two-mode squeezed states in such a platform could enable applications that are only viable with photons. Here, we experimentally demonstrate two-mode squeezed states by employing atoms in a two-dimensional optical lattice as quantum registers. The states are generated by a controlled projection conditioned on the relative phase of two independent squeezed states. The individual squeezing is created by sudden jumps of the oscillators' frequencies, allowing generating of the two-mode squeezed states at a rate within a fraction of the oscillation frequency. We validate the states by entanglement steering criteria and Fock state analysis. Our results can be applied in other mechanical oscillators for quantum sensing and continuous-variable quantum information.
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http://dx.doi.org/10.1103/PhysRevLett.131.193601 | DOI Listing |
Nat Chem Biol
January 2025
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Voltage-gated ion channels (VGICs) are crucial targets for neuropsychiatric therapeutics owing to their role in controlling neuronal excitability and the established link between their dysfunction and neurological diseases, highlighting the importance of identifying modulators with distinct mechanisms. Here we report two small-molecule modulators with the same chemical scaffold, Ebio2 and Ebio3, targeting a potassium channel KCNQ2, with opposite effects: Ebio2 acts as a potent activator, whereas Ebio3 serves as a potent and selective inhibitor. Guided by cryogenic electron microscopy, patch-clamp recordings and molecular dynamics simulations, we reveal that Ebio3 attaches to the outside of the inner gate, employing a unique non-blocking inhibitory mechanism that directly squeezes the S6 pore helix to inactivate the KCNQ2 channel.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
State Key Laboratory of Organic-Inorganic Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Hydrogels are popular materials for desalination and can significantly reduce the vaporization enthalpy of water; however, there are few reports on hydrogels with a controllable multilevel structural design for water evaporation. Herein, a calcium alginate and traditional Chinese ink-based evaporator (CIE) are proposed and fabricated using directed freezing technology to construct radial channels, followed by freeze-drying and physical cross-linking. Because of the squeezing of ice crystals and the shaping effect of the PDMS template, the prepared evaporator exhibits a sea-urchin-shaped highly geometrical centrosymmetric structure with numerous multilevel pore channels, which promotes the rapid transport of water under different solar incidence angles as the sun rotates as well as overcomes the structural shrinkage of the hydrogel caused by insufficient water supply.
View Article and Find Full Text PDFbioRxiv
December 2024
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06511, USA.
Cytoplasmic dynein-1, a microtubule-based motor protein, requires dynactin and an adaptor to form the processive dynein-dynactin-adaptor (DDA) complex. The role of microtubules in DDA assembly has been elusive. Here, we reveal detailed structural insights into microtubule-mediated DDA assembly using cryo-electron microscopy.
View Article and Find Full Text PDFSci Rep
January 2025
Key Laboratory of Instrumentation Science, Dynamic Measurement of Ministry of Education, North University of China, Taiyuan, 030051, Shanxi, China.
This paper propose a significantly enhanced YOLOv8 model specifically designed for detecting tongue fissures and teeth marks in Traditional Chinese Medicine (TCM) diagnostic images. By integrating the C2f_DCNv3 module, which incorporates Deformable Convolutions (DCN), replace the original C2f module, enabling the model to exhibit exceptional adaptability to intricate and irregular features, such as fine fissures and teeth marks. Furthermore, the introduction of the Squeeze-and-Excitation (SE) attention mechanism optimizes feature weighting, allowing the model to focus more accurately on key regions of the image, even in the presence of complex backgrounds.
View Article and Find Full Text PDFAm J Speech Lang Pathol
January 2025
Department of Communication Sciences and Disorders, The University of Iowa, Iowa City.
Purpose: This scoping review aimed to explore the use of volitional voice tasks in assessing swallowing-related outcomes and to evaluate their therapeutic impact on swallowing disorders, including their effects on swallowing biomechanics.
Method: This scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. A literature search was performed across multiple databases (PubMed, Web of Science, and Scopus), and additional records were identified through manual searches.
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