Postoperative cognitive dysfunction (POCD) is a common complication after surgery, characterized by deficits in memory, attention and cognitive flexibility. However, the underlying mechanisms of POCD remain unclear. Neuroinflammation and blood-brain barrier disruption have been implicated as potential pathological processes. This study explores the neuroprotective effects and mechanisms of the matrix metalloproteinase(MMP-9)inhibitor GM6001 against POCD. We hypothesize GM6001 may reduce neuroinflammation and preserve blood-brain barrier integrity through direct inhibition of MMP-9. Moreover, GM6001 may stabilize aquaporin-4 polarity and glymphatic clearance function by modulating MMP-9-mediated cleavage of dystroglycan, a key protein for aquaporin-4 anchoring. Our results demonstrate GM6001 alleviates postoperative cognitive deficits and neuroinflammation. GM6001 also preserves blood-brain barrier integrity and rescues aquaporin-4 mislocalization after surgery. This study reveals a novel dual role for MMP-9 inhibition in cognitive protection through direct anti-neuroinflammatory effects and regulating aquaporin-4 membrane distribution. Targeting MMP-9 may represent a promising strategy to prevent postoperative cognitive dysfunction by integrating multiple protective mechanisms.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.intimp.2023.111215 | DOI Listing |
Open Med (Wars)
December 2024
Department of Anesthesiology, Shanghai United Family Hospital, Shanghai 200050, China.
Background: Postoperative cognitive dysfunction (POCD) frequently occurs following endovascular therapy for acute ischemic stroke (AIS). Given the complexity of predicting AIS clinically, there is a pressing need to develop a preemptive prediction model and investigate the impact of anesthesia depth on AIS.
Methods: A total of 333 patients diagnosed with AIS were included in the study, comprising individuals with non-POCD ( = 232) or POCD ( = 101).
J Cardiothorac Surg
December 2024
Nanjing Medical University, Longmian Avenue No.101, Jiangning District, Nanjing, Jiangsu, China.
Background: Postoperative delirium (POD) is a cognitive decline and attention deficit that can occur in patients after cardiac surgery. Despite extensive research identifying the risk factors, POD often remains undiagnosed and untreated in medical settings. Therefore, this systematic literature review (SLR) aimed to summarize the available studies on early POD identification in patients following cardiovascular surgery.
View Article and Find Full Text PDFBr J Anaesth
December 2024
Department of Anaesthesiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address:
Background: Systemic inflammation after heart valve replacement surgery commonly results in complications including cognitive impairment. This study was designed to investigate whether valvular heart disease itself and inflammation after valve replacement surgery affects cognition and the related functional connectivity (FC) of the hippocampal memory network.
Methods: Forty-three patients with valvular heart disease were screened for recruitment and assessed with cognition function tests, blood inflammatory cytokine measurements, and functional magnetic resonance imaging scans before surgery and on postoperative day 7 and 30.
BMC Res Notes
December 2024
Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Oko-cho, Kohasu, Nankoku, 783-8505, Kochi, Japan.
Objective: This study examines the impact of preoperative stress on postoperative neuroinflammation and associated cognitive dysfunction, with a focus on aged individuals. The goal is to determine whether managing preoperative stress can enhance postoperative outcomes and lower the risk of cognitive impairment.
Results: In aged rats, preoperative restraint stress significantly worsened neuroinflammation and cognitive deficits following abdominal surgery.
World Neurosurg
December 2024
Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou, Gansu Province, China.
Background: Perioperative neurocognitive disorders (PND) are common perioperative complications associated with various poor outcomes. Regional cerebral oxygen saturation (rSO2) monitoring is a non-invasive technique based on near-infrared spectroscopy detection. Due to the considerable controversy among currently published studies on the application of intraoperative rSO2 monitoring in adult patients undergoing elective non-cardiac surgery, this study aims to conduct a systematic review and meta-analysis to provide more comprehensive and robust evidence to support clinical decision-making.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!