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Structural Characterization and Cytotoxic Activity Evaluation of Ulvan Polysaccharides Extracted from the Green Algae . | LitMetric

AI Article Synopsis

  • Ulvan, a sulfated heteropolysaccharide extracted from an unexplored green seaweed species in the South China Sea, yields approximately 15% by dry weight and contains 13.4 wt% sulfate, with a specific composition of various sugars in defined ratios.
  • Structural analysis of ulvan revealed two distinct forms, A3s and B3s, using methods like HPLC, FT-IR, and NMR, with a relative abundance of 1:1.5.
  • Ulvan demonstrated significant antitumor activity against multiple human cancer cell lines and showed acceptable safety profiles in QSAR modeling, suggesting its potential as a viable pharmaceutical for cancer treatment.

Article Abstract

Ulvan, a sulfated heteropolysaccharide with structural and functional properties of interest for various uses, was extracted from the green seaweed . is an unexplored species found in the South China Sea along the central coast of Vietnam. Based on dry weight, the ulvan yield was ~15% (/) and the ulvan had a sulfate content of 13.4 wt%. The compositional constitution encompassed L-Rhamnose (Rha), D-Xylose (Xyl), D-Glucuronic acid (GlcA), L-Iduronic acid (IdoA), D-Galactose (Gal), and D-Glucose (Glc) with a molar ratio of 1:0.19:0.35:0.52:0.05:0.11, respectively. The structure of ulvan was determined using High-Performance Liquid Chromatography (HPLC), Fourier Transform Infrared Spectroscopy (FT-IR), and Nuclear Magnetic Resonance spectroscopy (NMR) methods. The results showed that the extracted ulvan comprised a mixture of two different structural forms, namely ("A3s") with the repeating disaccharide [→4)-β-D-GlcA-(1→4)-α-L-Rha 3S-(1→]n, and ("B3s") with the repeating disaccharide [→4)-α-L-IdoA-(1→4)-α-L-Rha 3S(1→]n. The relative abundance of A3s, and B3s was 1:1.5, respectively. The potential anticarcinogenic attributes of ulvan were evaluated against a trilogy of human cancer cell lineages. Concomitantly, Quantitative Structure-Activity Relationship (QSAR) modeling was also conducted to predict potential adverse reactions stemming from pharmacological interactions. The ulvan showed significant antitumor growth activity against hepatocellular carcinoma (IC ≈ 90 µg/mL), human breast cancer cells (IC ≈ 85 µg/mL), and cervical cancer cells (IC ≈ 67 µg/mL). The QSAR models demonstrated acceptable predictive power, and seven toxicity indications confirmed the safety of ulvan, warranting its candidacy for further in vivo testing and applications as a biologically active pharmaceutical source for human disease treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10672449PMC
http://dx.doi.org/10.3390/md21110556DOI Listing

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