Evaluation of the BD Phoenix Carbapenemase-Producing Organism Panels for the Detection of Carbapenemase Producers in and .

The classification of carbapenemases can help guide therapy. The present study evaluated the performance of the CPO detection test, included in the BD Phoenix NMIC-501 panel for the detection and classification of carbapenemases on the representative molecularly characterized strains collection from Mexico. Carbapenem non-susceptible isolates collected in Mexico were included. The clinical isolates ( = 484) comprised ( = 154), ( = 150), and ( = 180). BD Phoenix CPO NMIC-504 and NMIC-501 panels were used for the identification of species, antimicrobial susceptibility tests, and detection of CPOs. For the detection of carbapenemase-encoding genes, and were evaluated using PCR assays for , , , , and . For , VIM, IMP, and GES were detected using PCR. Regarding , the CPO panels had a sensitivity of 70% and specificity of 83.33% for the detection of a class B carbapenemase ( in the molecular test). Regarding , the panels had a sensitivity of 75% and specificity of 100% for the detection of a class A carbapenemase ( in the molecular test). The Phoenix NMIC-501 panels are reliable for detecting class B carbapenemases in . The carbapenemase classification in for class A carbapenemases has a high specificity and PPV; thus, a positive result is of high value.