Jogyamycin is a densely functionalized aminocyclopentitol that displays potent antiprotozoal activity. Herein, we report a route toward this natural product that utilizes an unprecedented transformation involving a tandem Ichikawa-Winstein rearrangement to install the C-1/C-2 diamine core. Attempts to further functionalize the C-3/C-4 alkene en route to jogyamycin are also discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789149 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.3c03286 | DOI Listing |
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