Elevated GSH and HO in cancer cells is sometimes doubted due to their contrary reactivities. Here, we construct a dual-responsive fluorescent probe to confirm the conclusion, and employ this to exploit a redox-inducible DNA interstrand crosslink (ICL) precursor. It crosslinks DNA upon activation by GSH and HO, affording an alternative dual-responsive strategy.
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| http://dx.doi.org/10.1039/d3cc05175g | DOI Listing |
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