AI Article Synopsis
- Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder that presents with autonomic dysfunction alongside parkinsonism or cerebellar signs, marked by the accumulation of alpha-synuclein in oligodendrocytes.
- The study utilized the Unified MSA Rating Scale (UMSARS), imaging, and cardiovascular tests to evaluate MSA patients from early stages, finding UMSARS effective for monitoring progression and gauging risk of severe outcomes.
- By detailing the clinical and pathological characteristics of MSA, the study suggests that standardized testing combined with neuropathological findings can improve diagnosis accuracy and sensitivity in distinguishing MSA from other disorders.
Article Abstract
Background And Objective: Multiple system atrophy is a rare and fatal neurodegenerative disorder, characterized by autonomic dysfunction in association with either parkinsonism or cerebellar signs. The pathologic hallmark is the presence of alpha-synuclein aggregates in oligodendrocytes, forming glial cytoplasmic inclusions. Clinically, it may be difficult to distinguish form other parkinsonisms or ataxias, particularly in the early stages of the disease. In this case series we aim to describe in detail the features of MSA patients.
Material And Methods: Unified MSA Rating Scale (UMSARS) score, structural and functional imaging and cardiovascular autonomic testing, are summarized since early stages of the disease.
Results: UMSARS proved to be useful to perform a follow-up being longitudinal examination essential to stratify risk of poor outcome. Neuropathological diagnosis showed an overlap between parkinsonian and cerebellar subtypes, with some peculiarities that could help to distinguish from other subtypes.
Conclusion: A better description of MSA features with standardized test confirmed by means of neuropathological studies could help to increase sensitivity.
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| http://dx.doi.org/10.1016/j.nrleng.2021.04.008 | DOI Listing |
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