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A Network Biology-Guided Investigation of the Long Noncoding RNAs' Role in Glaucoma.
Methods Mol Biol
December 2024
Department of Biotechnology, Raipur Institute of Technology, Raipur, Chhattisgarh, India.
Glaucoma is a group of eye diseases characterized by progressive harm to the optic nerve that often results in loss of vision and blindness. Recent studies suggest that deregulation in the expression of a particular type of RNAs named long noncoding RNAs (lncRNAs) can impact the development of glaucoma and, hence, are promising targets for drug discovery. LncRNAs are transcripts with a length longer than 200 nucleotides that are not translated into proteins.
View Article and Find Full Text PDFCATALYZE: A DEEP LEARNING APPROCH FOR CATARACT ASSESSEMENT AND GRADING ON SS-OCT ANTERION IMAGES.
J Cataract Refract Surg
December 2024
Department of Ophthalmology, Rothschild Foundation, 25, Rue Manin, 75019, Paris, France.
Purpose: To assess an new objective deep learning model cataract grading method based on Swept-Source Optical Coherence Tomography (SS-OCT) scans provided by the Anterion® (Heidelberg, Germany).
Setting: Single centre study at the Rothschild Foundation, Paris, France.
Design: Prospective cross-sectional study.
High-Resolution Eye-Tracking System for Accurate Measurement of Short-Latency Ocular Following Responses: Development and Observational Study.
JMIR Pediatr Parent
December 2024
Institute for Maternal and Child Health-IRCCS, Trieste, 34100, Italy, 39 0405587124.
Background: Ocular following responses (OFRs)-small-amplitude, short-latency reflexive eye movements-have been used to study visual motion processing, with potential diagnostic applications. However, they are difficult to record with commercial, video-based eye trackers, especially in children.
Objective: We aimed to design and develop a noninvasive eye tracker specialized for measuring OFRs, trading off lower temporal resolution and a smaller range for higher spatial resolution.
Evaluation of design parameters on the outcome of intrastromal ring surgery using biomechanical simulations.
PLoS One
December 2024
ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.
Background: The cornea plays a role in the refractive power of the eye, and when its natural curvature and thickness are compromised by diseases such as keratoconus or high myopia, this results in loss of visual acuity. Intracorneal rings (ICRs) were developed as a treatment option to restore the natural corneal curvature by implanting rings into tunnels cut within the corneal stroma. However, selecting and placing the appropriate ring can be difficult, and predicting refractive outcomes is challenging.
View Article and Find Full Text PDFInvestigation of Astyanax mexicanus (Characiformes, Characidae) chromosome 1 structure reveals unmapped sequences and suggests conserved evolution.
PLoS One
November 2024
Departamento de Biologia Estrutural, Molecular e Genética, Programa de Pós-Graduação em Biologia Evolutiva, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brazil.
Article Synopsis
- - The Mexican tetra, Astyanax mexicanus, has evolved unique traits like pigment loss due to natural selection in cave habitats and serves as an important species for studying evolution, with a chromosome count of 2n = 50.
- - Researchers utilized advanced techniques including whole chromosome isolation and sequencing to analyze the structure of a specific chromosome (chromosome 1) in A. mexicanus, contributing to the understanding of its genetic makeup.
- - Findings showed strong conservation of chromosome features across related species, suggesting a shared evolutionary origin, and the gathered data can be useful for comparative studies in other fish species of the same family.
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