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Mesenchymal stem cell-derived exosomes carrying miR-486-5p inhibit glycolysis and cell stemness in colorectal cancer by targeting NEK2.
BMC Cancer
November 2024
Department of Oncology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, No. 7 Weiwu Road, Jinshui District, Zhengzhou City, 450003, Henan, China.
Article Synopsis
- * Research involved isolating human umbilical cord-derived MSC-EXOs and conducting various assays to evaluate their effects on CRC cell proliferation, glycolysis, and stemness, revealing that MSC-EXOs can inhibit these cancer-promoting activities.
- * A key finding was that the exosomal microRNA miR-486-5p, which is downregulated in CRC cells, binds to and inhibits the protein NEK2, suggesting that targeting this pathway could enhance therapeutic strategies against colorectal cancer
In Brief: Insufficiency of extravillous trophoblast (EVT) cell invasion is implicated in pregnancy complications. This study reveals the roles of the miR-486-5p/Smad2 pathway in lipopolysaccharide (LPS)-induced EVT dysfunctions and in the pathogenesis of early pregnancy loss (EPL).
Abstract: Placenta-associated pathologies, including EPL and preeclampsia, are characterized by insufficient EVT invasion.
S-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis.
J Nanobiotechnology
October 2024
Department of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao, 266071, People's Republic of China.
Article Synopsis
- Radiation-induced lung injury (RILI) causes cell death and fibrosis in lungs, but MSC-derived exosomes can help, although they lack targeting abilities and specific effects.
- A study engineered these exosomes with the SARS-CoV-2 spike protein and the miRNA miR-486-5p to enhance their therapeutic effects.
- The modified exosomes promoted lung cell growth and migration, reduced RILI and fibrosis, and inhibited ferroptosis by regulating fibrosis-related genes both in vitro and in vivo.
Exosomes from hypoxic urine-derived stem cells facilitate healing of diabetic wound by targeting SERPINE1 through miR-486-5p.
Biomaterials
March 2025
Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Frontier Medical Center, Tianfu Jincheng Laboratory, Chengdu, Sichuan, 610212, PR China. Electronic address:
Article Synopsis
- * The study enhances the angiogenic properties of exosomes from urine-derived stem cells (USCs) by preconditioning them in hypoxia and uses a specially engineered hydrogel, SISMA, to effectively deliver these exosomes at wound sites.
- * Results show that this hypoxia-treated exosome-loaded hydrogel boosts cell proliferation, migration, and tissue regeneration in injuries, potentially via the activation of HIF-1α signaling and miR-486-5p's role in regulating endothelial cell activity.
miR-486-5p diagnosed atrial fibrillation, predicted the risk of left atrial fibrosis, and regulated angiotensin II-induced cardiac fibrosis via modulating PI3K/Akt signaling through targeting FOXO1.
Mol Cell Biochem
May 2024
Department of Cardiology, Affiliated Hospital of Hebei University, No. 212, Yuhua East Road, Baoding, 071000, People's Republic of China.
This study focused on miR-486-5p in atrial fibrillation (AF) evaluating its clinical significance and revealing its regulatory mechanism in cardiac fibroblasts, aiming to explore a novel biomarker for AF. The study enrolled 131 AF patients and 77 non-AF individuals. With the help of polymerase chain reaction (PCR), the expression of miR-486-5p was evaluated.
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