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Evaluating the use of Uromune autovaccine in recurrent urinary tract infections: a pilot unicenter retrospective study in Reus, Spain.
BMC Infect Dis
January 2025
Department of Urology, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
Background: Urinary tract infections (UTIs) are a significant global health issue, especially among women, with growing concerns related to antibiotic resistance and adverse effects. The Uromune, a sublingual, heat-inactivated, polybacterial vaccine, represents a promising therapeutic alternative by enhancing immune responses against uropathogens.
Methods: This pilot retrospective study, conducted at Hospital Universitari de Sant Joan de Reus from January 2018 to August 2022, assessed the association between Uromune administration and changes in recurrent UTIs.
Integrated Phase I Pharmacokinetics and Pharmacodynamics of Epinephrine Administered via Sublingual Film, Autoinjector, or Manual Injection.
Ann Allergy Asthma Immunol
January 2025
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Epinephrine is the first-line treatment for anaphylaxis and is administered via intramuscular (IM) or subcutaneous (SC) injection. AQST-109, a sublingual film containing a prodrug of epinephrine, is in development as an alternative delivery method for the treatment of severe allergic reactions including anaphylaxis.
Objective: To compare the pharmacokinetics (PK) and pharmacodynamics (PD) of epinephrine following administration of AQST-109 to epinephrine delivered by manual IM injection and epinephrine autoinjectors (EAIs).
Adjuvant Effect of in Sublingual Immunotherapy of Asthmatic Mice.
Pharmaceuticals (Basel)
November 2024
Department of Pathogen Biology and Microecology, School of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
: Sublingual immunotherapy (SLIT) has shown promise in mitigating allergic asthma symptoms; nevertheless, its high dose and prolonged duration of treatment raise safety concerns. This study explored the potential of () to enhance the effectiveness of SLIT in a mouse model of allergic asthma. : Allergic asthma was induced in Balb/c mice following sensitization and challenge with a house dust mite (HDM) allergen.
View Article and Find Full Text PDFSurgical extraction of a sublingually-displaced retained root with the aid of a magnetic field-based dynamic navigation system: a case study.
J Korean Assoc Oral Maxillofac Surg
December 2024
Department of Oral and Maxillofacial Surgery, Hallym University Sacred Heart Hospital, Anyang, Korea.
Article Synopsis
- The extraction of a submandibular-displaced mandibular third molar root is challenging for surgeons due to its closeness to important structures like the lingual nerve and sublingual artery.
- Preoperative imaging helps locate the root, but real-time synchronization is tough because of the mandible's moving nature.
- This study highlights the successful extraction of a residual root using a magnetic navigation system, resulting in a minimally invasive procedure with no complications or major issues reported postoperatively.
A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy.
Drug Deliv
December 2025
University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary.
Drug-loaded liposomes incorporated in nanofibrous scaffolds is a promising approach as a multi-unit nanoscale system, which combines the merits of both liposomes and nanofibers (NFs), eliminating the drawback of liposomes' poor stability on the one hand and offering a higher potential of controlled drug release and enhanced therapeutic efficacy on the other hand. The current systematic review, which underwent a rigorous search process in PubMed, Web of Science, Scopus, Embase, and Central (Cochrane) employing (Liposome AND nanofib* AND electrosp*) as search keywords, aims to present the recent studies on using this synergic system for different therapeutic applications. The search was restricted to original, peer-reviewed studies published in English between 2014 and 2024.
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