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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM" IndexingMethod="Automated"><PMID Version="1">37992609</PMID><DateCompleted><Year>2024</Year><Month>01</Month><Day>16</Day></DateCompleted><DateRevised><Year>2024</Year><Month>01</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7727</ISSN><JournalIssue CitedMedium="Internet"><Volume>170</Volume><PubDate><Year>2024</Year><Month>Jan</Month></PubDate></JournalIssue><Title>European journal of radiology</Title><ISOAbbreviation>Eur J Radiol</ISOAbbreviation></Journal><ArticleTitle>Ultra-high resolution photon-counting CT with tin prefiltration for bone-metal interface visualization.</ArticleTitle><Pagination><StartPage>111209</StartPage><MedlinePgn>111209</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejrad.2023.111209</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0720-048X(23)00523-5</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To investigate the metal artifact suppression potential of combining tin prefiltration and virtual monoenergetic imaging (VMI) for osseous microarchitecture depiction in ultra-high-resolution (UHR) photon-counting CT (PCCT) of the lower extremity.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">Derived from tin-filtered UHR scans at 140 kVp, polychromatic datasets (T3D) and VMI reconstructions at 70, 110, 150, and 190&#xa0;keV were compared in 117 patients with lower extremity metal implants (53 female; 62.1&#xa0;&#xb1;&#xa0;18.0&#xa0;years). Three implant groups were investigated (total arthroplasty [n&#xa0;=&#xa0;48], osteosynthetic material [n&#xa0;=&#xa0;43], and external fixation [n&#xa0;=&#xa0;26]). Image quality was assessed with regions of interest placed in the most pronounced artifacts and adjacent soft tissue, measuring the respective attenuation. Additionally, artifact extent, bone-metal interface interpretability and overall image quality were independently evaluated by three radiologists.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Artifact reduction was superior with increasing keV level of VMI. While T3D was superior to VMI<sub>70keV</sub> (p&#xa0;&#x2265;&#xa0;0.117), artifacts were more severe in T3D than in VMI&#xa0;&#x2265;&#xa0;110&#xa0;keV (all p&#xa0;&#x2264;&#xa0;0.036). Image noise was highest for VMI<sub>70keV</sub> (all p&#xa0;&lt;&#xa0;0.001) and lowest for VMI<sub>110keV</sub> with comparable results for VMI<sub>110keV</sub> - VMI<sub>190keV</sub>. Subjective image quality regarding artifacts was superior for VMI&#xa0;&#x2265;&#xa0;110&#xa0;keV (all p&#xa0;&#x2264;&#xa0;0.042) and comparable for VMI<sub>110keV</sub> - VMI<sub>190keV</sub>. Bone-metal interface interpretability was superior for VMI<sub>110keV</sub> (all p&#xa0;&#x2264;&#xa0;0.001), while T3D, VMI<sub>150keV</sub> and VMI<sub>190keV</sub> were comparable. Overall image quality was deemed best for VMI<sub>110keV</sub> and VMI<sub>150keV</sub>. Interreader reliability was good in all cases (ICC&#xa0;&#x2265;&#xa0;0.833).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Tin-filtered UHR-PCCT scans of the lower extremity combined with VMI reconstructions allow for efficient artifact reduction in the vicinity of bone-metal interfaces.</AbstractText><CopyrightInformation>Copyright &#xa9; 2023 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Patzer</LastName><ForeName>Theresa Sophie</ForeName><Initials>TS</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital W&#xfc;rzburg, Oberd&#xfc;rrbacher Stra&#xdf;e 6, 97080 W&#xfc;rzburg, Germany. Electronic address: Patzer_T@ukw.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grunz</LastName><ForeName>Jan-Peter</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital W&#xfc;rzburg, Oberd&#xfc;rrbacher Stra&#xdf;e 6, 97080 W&#xfc;rzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huflage</LastName><ForeName>Henner</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital W&#xfc;rzburg, Oberd&#xfc;rrbacher Stra&#xdf;e 6, 97080 W&#xfc;rzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hennes</LastName><ForeName>Jan-Lucca</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital W&#xfc;rzburg, Oberd&#xfc;rrbacher Stra&#xdf;e 6, 97080 W&#xfc;rzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pannenbecker</LastName><ForeName>Pauline</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital W&#xfc;rzburg, Oberd&#xfc;rrbacher Stra&#xdf;e 6, 97080 W&#xfc;rzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruschwitz</LastName><ForeName>Philipp</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital W&#xfc;rzburg, Oberd&#xfc;rrbacher Stra&#xdf;e 6, 97080 W&#xfc;rzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Afat</LastName><ForeName>Saif</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital T&#xfc;bingen, Hoppe-Seyler-Str 3, 72076 T&#xfc;bingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herrmann</LastName><ForeName>Judith</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital T&#xfc;bingen, Hoppe-Seyler-Str 3, 72076 T&#xfc;bingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bley</LastName><ForeName>Thorsten Alexander</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital W&#xfc;rzburg, Oberd&#xfc;rrbacher Stra&#xdf;e 6, 97080 W&#xfc;rzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kunz</LastName><ForeName>Andreas Steven</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Diagnostic and Interventional Radiology, University Hospital T&#xfc;bingen, Hoppe-Seyler-Str 3, 72076 T&#xfc;bingen, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2023</Year><Month>11</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Eur J Radiol</MedlineTA><NlmUniqueID>8106411</NlmUniqueID><ISSNLinking>0720-048X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>7440-31-5</RegistryNumber><NameOfSubstance UI="D014001">Tin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008670">Metals</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014001" MajorTopicYN="Y">Tin</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014057" MajorTopicYN="Y">Tomography, X-Ray Computed</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019736" MajorTopicYN="N">Prostheses and Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008670" MajorTopicYN="N">Metals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016477" MajorTopicYN="N">Artifacts</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011857" MajorTopicYN="N">Radiographic Image Interpretation, Computer-Assisted</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059629" MajorTopicYN="N">Signal-To-Noise Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cancellous bone</Keyword><Keyword MajorTopicYN="N">Metal artifact reduction</Keyword><Keyword MajorTopicYN="N">Photon-counting</Keyword><Keyword MajorTopicYN="N">Tin prefiltration</Keyword><Keyword MajorTopicYN="N">Tomography, x-ray computed</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The Department of Diagnostic and Interventional Radiology receives research funding from the German Research Foundation (DFG) for photon-counting CT studies. Jan-Peter Grunz [grant number Z-3BC/02], Philipp Gruschwitz [grant number Z-02CSP/18] and Theresa Sophie Patzer [grant number ZZ-36] are financially supported by the Interdisciplinary Center of Clinical Research W&#xfc;rzburg. Thorsten Alexander Bley, Andreas Steven Kunz and Jan-Peter Grunz have received speaker honoraria from Siemens Healthineers within the past three years. The Department of Diagnostic and Interventional Radiology receives ongoing research funding by Siemens Healthineers outside of the presented work. The authors of this manuscript declare no further relationships with any companies, whose products or services may be related to the subject matter of the article.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2023</Year><Month>9</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2023</Year><Month>11</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2023</Year><Month>11</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2024</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>41</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2023</Year><Month>11</Month><Day>23</Day><Hour>0</Hour><Minute>42</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2023</Year><Month>11</Month><Day>22</Day><Hour>18</Hour><Minute>11</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">37992609</ArticleId><ArticleId IdType="doi">10.1016/j.ejrad.2023.111209</ArticleId><ArticleId IdType="pii">S0720-048X(23)00523-5</ArticleId></ArticleIdList></PubmedData></PubmedArticle></PubmedArticleSet>