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Hyperthermia suppresses the biological characteristics and migration of chicken primordial germ cells.
Front Genome Ed
January 2025
State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, China.
Primordial germ cells (PGCs) play a crucial role in transmitting genetic information to the next-generation. In chickens, genetically edited PGCs can be propagated and subsequently transplanted into recipient embryos to produce offspring with desired genetic traits. However, during early embryogenesis, the effects of external conditions on PGC migration through the vascular system to the gonads have yet to be explored, which may affect the efficiency of preparing gene-edited chickens.
View Article and Find Full Text PDFImproving the preoperative assessment of older adults considering surgery: The need for a structured curriculum during surgery residency.
Surg Pract Sci
September 2023
Department of Medicine, Yale School of Medicine, PO Box 208062, New Haven, CT 06520-8088, USA.
Background: Over half of surgeries in the United States are performed on older adults. The aims of this study were to quantify geriatric-relevant discussion topics and assessments during the consent process and to assess the need for a structured approach to consent older patients.
Methods: General surgery residents at a single institution answered questions about content of the informed consent process and preoperative assessment in adult and geriatric (> 65) patients.
THE USE OF ORAL BISPHOSPHONATES IN REFRACTORY SEVERE HYPERCALCEMIA AFTER DENOSUMAB CESSATION.
Acta Endocrinol (Buchar)
January 2025
Ankara University School of Medicine, Department of Pediatric Endocrinology.
Unlabelled: Denosumab,a monoclonal IgG2 antibody directed against RANK-L,is used as a neoadjuvant therapy for inoperable or metastatic giant cell tumor of bone. Many side effects like as hypocalcemia during treatment and rarely severe hypercalcemia especially in children after discontinuation of denosumab occurred. The unpredictable onset and recurrent episodes of severe hypercalcemia increase the duration of hospitalization and the risk of complications.
View Article and Find Full Text PDFBackbone Hydration of -Helical Peptides: Hydrogen-Bonding and Surface Hydrophobicity/Hydrophilicity.
Mol Phys
March 2024
Department of Physics, Brooklyn College of the City University of New York, Brooklyn, NY 11210, United States.
The stability of proteins and small peptides depends on the way they interact with the surrounding water molecules. For small peptides, such as -helical polyalanine (polyALA), water molecules can weaken the intramolecular hydrogen-bonds (HB) formed between the peptide backbone O and NH groups which are responsible for the -helix structure. Here, we perform molecular dynamics simulations to study the hydration of polyALA, polyserine (polySER), and other homopolymer peptide -helices at different temperatures and pressures.
View Article and Find Full Text PDFTriangular-shaped Cu-Zn-In-Se-based nanocrystals with narrow near infrared photoluminescence.
Nanoscale
January 2025
Physical Chemistry, TU Dresden, Zellescher Weg 19, 01069 Dresden, Germany.
Tunable optical properties exhibited by semiconductor nanocrystals (NCs) in the near infrared (NIR) spectral region are of particular interest in various applications, such as telecommunications, bioimaging, photodetection, photovoltaics, . While lead and mercury chalcogenide NCs do exhibit exemplary optical properties in the NIR, Cu-In-Se (CISe)-based NCs are a suitable environment-friendly alternative to these toxic materials. Several reports of NIR-emitting (quasi)spherical CISe NCs have been published, but their more complex-shaped counterparts remain rather less explored.
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