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Hypobaric hypoxia drives selection of altitude-associated adaptative alleles in the Himalayan population.
Sci Total Environ
February 2024
Genomics and Molecular Medicine, CSIR-Institute of Genomics and Integrative Biology, Delhi 110007, India; Institute of Hypoxia Research, New Delhi 110067, India. Electronic address:
Genetic variants play a crucial role in shaping the adaptive phenotypes associated with high-altitude populations. Nevertheless, a comprehensive understanding of the specific impacts of different environments associated with increasing altitudes on the natural selection of these genetic variants remains undetermined. Hence, this study aimed to identify genetic markers responsible for high-altitude adaptation with specific reference to different altitudes, majorly focussing on an altitude elevation range of ∼1500 m and a corresponding decrease of ≥5 % in ambient oxygen availability.
View Article and Find Full Text PDF[Clinico-physiological parameters of diabetic polyneuropathy in elderly patients with diabetes mellitus type II and the treatment].
Adv Gerontol
July 2018
I. I. Mechnikov North-Western State Medical University, St. Petersburg, 193015, Russian Federation;
Changes of subjective and objective symptoms, elektroneyromiographic parameters, analysis of vegetative system were perfomed in 120 patients with diabetes mellitus type 2. The obtained results show the dependence of subjective and objective manifestations from the duration of the disease.
View Article and Find Full Text PDF[Clinico-physiological analysis of cranial dystonia].
Zh Nevrol Psikhiatr Im S S Korsakova
April 2000
To study afferent and efferent mechanisms of both pathogenesis and forming of the symptoms of dystonia a clinical-electrophysiologic examination was performed in 22 aged 35-69 years patients with cranial dystonia. A wide range of different factors in anamnesis of the patients was found, that had had either short or long influence on the facial zone and that had preceded the development of cranial dystonia (2 month-5 years before its rise). This was called by the authors the peripheral factor of dystonia pathogenesis.
View Article and Find Full Text PDFClinical (neurological), neurophysiological (EEG) and psychological examinations were carried out in 3 children with general speech defects. These children represented 3 main groups with speech disturbances: with speech defects which may be logopedically corrected, with speech defect and intact intellectual ability, with considerable disturbances of speech and cognitive functions. The peculiarities of cognitive disturbances were determined in each group.
View Article and Find Full Text PDFReflex reversal of apnoeic episodes by electrical stimulation of upper airway in cats.
Respir Physiol
December 1995
Department of Pathophysiology, Faculty of Medicine, Safarik University, Slovakia.
Respiratory effects of electrical stimulation of the upper airways (UAW) before and during apnoeic episodes induced by nitrogen inhalation were studied in 9 anaesthetized cats. In eupnoeic animals these electrically-evoked reflexes comprise rapid and powerful inspiratory efforts characterized by strong maximal airway occlusion pressures (Pmax = 635 +/- 39 mm H2O) and rapid peak inspiratory flow rates (PIF = 536 +/- 36 ml.sec-1) similar to the sniff-like aspiration reflex elicited mechanically.
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